Chromatography Resin Market

Chromatography Resin Market Overview

The global chromatography resin market size was valued at USD 2.8 billion in 2023 and is projected to reach USD 4.1 billion by 2028, growing at 8.2% cagr during the forecast period. The market growth of chromatography resins is propelled by two key factors: the rising demand for biosimilars and the continuous expansion of pharmaceutical and biopharmaceutical R&D activities. Particularly, the growing demand for biosimilars in the Asia Pacific region is driving the need for chromatography resins, while further growth is anticipated in the US and Japan. As R&D spending continues to increase, the demand for chromatography resins is expected to grow, with their integral role in various pharmaceutical R&D processes.

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Market Dynamics

Driver: Growing demand for biosimilars

Biosimilars have proven effective in the treatment of various medical conditions such as cancer, rheumatoid arthritis, infectious disorders, psoriasis, anemia, kidney failure, type 1 and type 2 diabetes, post-menopausal osteoporosis, and hormonal disorders. Ongoing research and development efforts are focused on utilizing biosimilars in therapeutic areas, including oncology, autoimmune disorders, diabetes, and hepatitis. Furthermore, there is potential for biosimilars to be developed for other chronic conditions such as meningitis, breast cancer, adult T-cell leukemia, obesity, hypertension, and hepatitis E. The demand for biosimilars continues to rise, and the utilization of chromatography resins is expected to increase accordingly.  

Restraint: Shortage of suitably trained professionals

In recent years, the chromatography resin market has witnessed significant technological advancements. However, a pressing challenge in the pharmaceutical industry is the scarcity of skilled professionals who can effectively operate chromatography instruments and perform the necessary techniques. The successful utilization of chromatography equipment demands expertise, hands-on experience, and comprehensive knowledge of various chromatography techniques. This shortage of skilled labor has the potential to impede the growth of the global chromatography resins market. By nurturing a skilled labor force, the chromatography sector can thrive, fueling further advancements and expansion in the market.

Opportunity: Rising demand for chromatography in drug development and omics research

Chromatography is an exceptionally adaptable separation technique that offers extensive availability. During the initial stages of drug discovery, it is crucial to separate numerous closely related compounds that have been synthesized. The identification and assessment of their purity are of utmost importance. Chromatography methods are widely utilized for these purposes. Chromatography instruments find extensive applications in separating, purifying, and analyzing raw materials, Active Pharmaceutical Ingredients (APIs), and excipients. As a result, the growing need for high-quality medications and the implementation of stringent government regulations have led to an increased demand for chromatography resins in several countries.

Challenge: The presence of unconventional technologies in chromatography

There are various alternative techniques available that can serve as substitutes for chromatography, including precipitation, high-resolution ultrafiltration, crystallization, high-pressure refolding, charged ultrafiltration membranes, protein crystallization, capillary electrophoresis, aqueous two-phase extraction, three-phase partitioning, monoliths, and membrane chromatography. These alternative techniques offer distinct advantages, which may pose challenges to the growth of the chromatography resin market. The availability of these alternative methods introduces competition and prompts the industry to continuously innovate and enhance the performance and efficiency of chromatography resin to maintain its market position.

Chromatography resins market ecosystem

Preceding companies in this market include well-established, financially stable chromatography resins. These businesses have been in business for a while and have an extensive range of products, pioneering technologies, and strong international sales and marketing networks. Top companies in this market include Bio-Rad Laboratories Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), Tosoh Corporation (Japan), Bio-Works Technologies AB (Sweden), Avantor Performance Materials, Inc. (US), Mitsubishi Chemical Corporation (Japan).

“Synthetic resins are forecasted to be the fastest-growing chromatography resin type between 2023 and 2028.”

The synthetic resins segment is forecasted to exhibit the highest growth rate Between 2023 and 2028. The demand for synthetic resins is primarily fueled by their utilization in ion exchange chromatography. Among synthetic resins, polystyrene divinylbenzene stands out as the most frequently employed type due to its superior performance attributes when compared to natural polymers. The increasing adoption of the IEX technique further contributes to the growing prominence of polystyrene divinyl benzene. This surge in the synthetic resins segment is predominantly driven by the escalating usage of synthetic resins in analytical and laboratory-scale applications.

“Affinity was the largest chromatography technique in 2022 in terms of value.”

The principle of affinity chromatography revolves around the specific affinity between molecules in the mobile phase and ligands attached to the stationary resin. The affinity chromatography resin market segment is anticipated to experience growth due to the increasing need for protein A, which enables convenient and effective antibody purification. Affinity chromatography offers notable benefits, including excellent selectivity, resolution, and capacity in various protein purification processes. One of its advantages lies in leveraging a protein's inherent biological structure or function to facilitate purification. These factors collectively contribute to the rising demand for affinity chromatography techniques.

“Food & Beverages was the second-largest chromatography resin application in 2022 in terms of value.”

Chromatography resin plays a vital role as an analytical technique in food analysis, with its application primarily focused on three areas: assessing the nutritional quality of food, detecting spoilage, and identifying additives in food. The demand for chromatography resin in the food and beverage sector is driven by various factors. These include the rapid advancements in science and technology, the escalating costs of healthcare, the growing consumer preference for natural food products, the evolving lifestyles and dietary choices, and the increasing awareness of the importance of health and wellness. Additionally, the demand for beverages, dairy products, and natural ingredients such as food colors, flavors, flavonoids, and carotenoids further contributes to the need for chromatography resin in the food and beverage industry.

“North America to account for the largest share of the global chromatography resin market during the forecasted period between 2023 and 2028.”

In 2022, North America emerged as the dominant region in the global chromatography resin market, both in terms of volume and value. The United States stands as the leading market for chromatography resin in North America, closely followed by Canada. The strong presence of the therapeutic monoclonal antibody market in North America significantly contributes to the demand for chromatography resin. Moreover, modern chromatographic techniques are increasingly being employed for food analysis and various diagnostic applications in both the US and Canada. North America houses several prominent pharmaceutical companies, many of which have established their research centers in the region. These factors collectively drive the demand for chromatography resin in North America.

Source: Secondary Research, Expert Interviews, and MarketsandMarkets Analysis

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Key Market Players

The chromatography resin market is dominated by a few globally established players such as Danaher Corporation (US), Bio-Rad Laboratories Inc. (US), Merck KGaA (Germany), Tosoh Corporation (Japan), BioWorks Technologies AB (Sweden), and among others, are the key manufacturers that hold major market share in the last few years. The major focus was given to acquisition, innovation, and new product development due to the changing requirements of users across the world.  

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Scope of the Report

This report categorizes the global chromatography resin market based on type, technique, application, and region.

On the basis of type, the chromatography resin market has been segmented as follows:

• Synthetic Resins
• Natural Polymers
• Inorganic Media

On the basis of technique, the chromatography resin market has been segmented as follows:

• Ion Exchange
  • Cation
  • Anion
• Affinity
• Size Exclusion
• Hydrophobic Interaction
• Mixed Mode Chromatography Resin Market
• Others

On the basis of application, the chromatography resin market has been segmented as follows:

• Pharmaceutical & Biotechnology
  • Production
  • Academics & Research
• Food & Beverage
• Water & Environmental Analysis
• Others

On the basis of region, the chromatography resin market has been segmented as follows:

• North America
• Europe
• Asia Pacific
• Middle East & Africa
• South America

Recent Developments:

• In April 2020, Bio-Rad Laboratories, Inc. recently introduced its SARS-CoV-2 Total Ab test, a kit designed for blood-based immunoassays. This test aids in the identification of antibodies developed against SARS-CoV-2, the virus responsible for COVID-19. It has the capability to detect IgG, IgM, and IgA antibodies, offering a more comprehensive approach compared to tests that target a single immunoglobulin. The utilization of multiple immunoglobulins enhances the sensitivity of the assay, providing more accurate results in determining the presence of antibodies against SARS-CoV-2.
• In October 2021, Tosoh Bioscience LLC, a subsidiary of Tosoh Corporation, successfully finalized the acquisition of Semba Biosciences. Semba Biosciences is a renowned pioneer in the development of multi-column chromatography (MCC) instrumentation and technology, specifically for the downstream purification of biologics. This strategic acquisition has enabled Tosoh Biosciences to enhance and broaden its chromatography resin-related business.
• In March 2020, The acquisition of General Electric Company's life sciences division's Biopharma business by Danaher Corporation was successfully concluded. Following the acquisition, the business has been renamed Cytiva and will operate independently as a standalone company within Danaher's life sciences segment.

Frequently Asked Questions (FAQ):

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