Preparative and Process Chromatography Market

Updated on : Aug 22, 2024

Preparative and Process Chromatography Market Size, Share & Trends

The global preparative and process chromatography market, valued at US$10.6 billion in 2022, is forecasted to grow at a robust CAGR of 6.8%, reaching US$11.3 billion in 2023 and an impressive US$15.6 billion by 2028. The comprehensive research encompasses an exhaustive examination of industry trends, meticulous pricing analysis, patent scrutiny, insights derived from conferences and webinars, identification of key stakeholders, and a nuanced understanding of market purchasing dynamics.

The growth in this market is attributed to the increasing need for biosimilars, rising demand for insulin and monocolonal antibodies, and growing use of LCMS in research. However, alternative methods or techniques restrain the growth of this market.

Preparative and Process Chromatography Market Trends

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Global Preparative and process chromatography Dynamics

DRIVER: Increasing demand for insulin and other biopharmaceutical products

In insulin purification Process chromatography plays an important role. The growing demand for insulin due to the increasing prevalence of insulin-dependent diabetes. The International Diabetes Federation (IDF) stated that over 537 million people had diabetes worldwide in 2021. The IDF has also projected that, in 2030, over 643 million people may have diabetes; by 2045, the number will escalate to 783 million. The increasing awareness about the available treatments among patients and clinicians results and rising prevalence of diabetes in a growing demand for insulin worldwide. This trend is, in turn, driving the growth of the process chromatography market.

RESTRAINT: High cost of instruments

Preparative and process chromatography systems are priced at a premium because of the features and technologies involved. The requirement of such systems in processes is crucial in SMEs in the oil & gas, food & beverage, and biotech & pharmaceutical industries and research & academic institutions. Thus, the capital cost spent on these systems increases significantly. Moreover, as academic research laboratories have controlled budgets, they find it difficult to afford such systems. The maintenance costs and other indirect expenses result in an overall increase in the total cost of ownership of these instruments. This restricts the adoption of chromatographic accessories & consumables among price-sensitive end users, such as research laboratories, academic institutes, and small companies. For instance, Merck KGaA (Germany) offers resins for USD 120–58,066 and supported fluid extraction columns, accessories, etc., for USD 146–1,001. Agilent Technologies (US) offers GC systems for USD 902–19,249, while Shimadzu Corporation (Japan) offers GC systems for USD 14,613.

OPPORTUNITY: Increasing demand for mAbs

Preparative and process chromatography plays a crucial role in purifying monoclonal antibodies (mAbs). Major biopharmaceutical players such as Pfizer Inc. (US), Novartis International AG (Switzerland), Boehringer Ingelheim International GmbH (Germany), Amgen Inc. (US), and Samsung Bioepis (South Korea) have increased their focus on mAbs with such promising opportunities. Another key factor supporting the growth of the mAbs market the rising number of mAbs approved by regulatory bodies. As of February 2023, well over 100 novel mAbs3 were approved for cancer, autoimmune and infectious diseases, and inflammatory conditions, among other indications (Source: US FDA 2023). The growing number of mAbs available in the market is expected to increase the demand for the preparative and process chromatography technique, thereby supporting the growth of the market.

CHALLENGE: Shortage of skilled professionals

Expertise with relevant experience and knowledge of the technique, mechanism, principle, resins, type of separation, and column packing is required for proper usage of chromatographic analytical technologies. Due to the lack of profound knowledge will likely incur several direct and indirect expenses, besides increasing researchers’ workload and time pressure which will also lead to inefficient practical experience and an insufficient understanding of data output. There is a significant shortage of skilled personnel for method development, validation, operation, and troubleshooting activities, which is expected to restrain the growth of the chromatography market in the coming years.

Preparative and Process Chromatography Ecosystem

Prominent companies in this market include well-established, financially stable manufacturers of preparative and process chromatography. These companies have been operating in the market for several years and possess diversified state-of-the-art technologies, product portfolios, and strong global sales and marketing networks. Prominent companies in this market include Thermo Fisher Scientific Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), Sartorius AG (Germany), and Bio-Rad Laboratories, Inc. (US).

In 2022, Process chromatography segment to observe the highest growth rate of the preparative and process chromatography industry, by type.

Based on type, the preparative and process chromatography market is classified into preparative chromatography and process chromatography. Each segment has been further divided based on product and service. The process chromatography segment dominated the market in 2022. The large share of the segment can be attributed to the growing number of players in the process chromatography products and rise in number of research projects such as proteomics and genomics.

In 2022, pharmaceutical and biotechnology industries segment to dominate the preparative and process chromatography industry, by end user.

Based on the end user, the preparative and process chromatography market is segmented into pharmaceutical & biotechnology industries, food & nutraceutical industries, and research laboratories. The pharmaceutical & biotechnology industries segment dominated the market in 2022. The large share of this segment can be primarily attributed to the growing investments in pharmaceutical manufacturing sites and growing production of mAbs and insulin in industries like biotechnology and biopharmaceuticals.

In 2022, North America to dominate in preparative and process chromatography industry.

The global preparative and process chromatography market is segmented into North America, Europe, Asia Pacific, and Rest of the World. North America is expected to dominate during the forecast period, primarily due to the growing R&D expenditure by pharmaceutical & biotechnology companies, growing demand for insulin products, and rise in research funding for food safety testing.

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The preparative and process chromatography market is dominated by players such as Thermo Fisher Scientific Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), Sartorius AG (Germany), and Bio-Rad Laboratories, Inc. (US).

Scope of the Preparative and Process Chromatography Industry

This research report categorizes the preparative and process chromatography market to forecast revenue and analyze trends in each of the following submarkets:

By Region

• North America
• Europe
• Asia Pacific
• Rest of the World

By Type

• Process chromatography
• Preparative chromatography

By End User

• Pharmaceutical & Biotechnology Industries
• Food & Nutraceutical Industries
• Research Laboratories

Recent Developments of Preparative and Process Chromatography Industry

• In 2023, Thermo Fisher acquired MarqMetrix, a privately held developer of Raman-based spectroscopy solutions for inline measurement. The acquisition added highly complementary Raman-based inline PAT to Thermo Fisher’s portfolio.
• In 2023, Waters Corporation and Sartorius collaborated to develop integrated analytical solutions for downstream biomanufacturing, expanding their joint agreement that began with upstream bioprocessing analytics.
• In 2022, Shimadzu Corporation developed the Brevis GC-2050. This new space-saving GC delivers high analytical performance in a rugged design to meet laboratory requirements.

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