Membrane Chromatography Market

Membrane Chromatography Market Size, Share & Trends

The size of global membrane chromatography market in terms of revenue was estimated to be worth $321 million in 2024 and is poised to reach $637 million by 2029, growing at a CAGR of 14.7% from 2024 to 2029. The comprehensive research encompasses an exhaustive examination of industry trends, meticulous pricing analysis, patent scrutiny, insights derived from conferences and webinars, identification of key stakeholders, and a nuanced understanding of market purchasing dynamics.

The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. Growth of the can be attributed to factors such as the rising demand for biopahramceuticals and increasing focus on advancement of biotechnology sector. However, restrictions on use of fluorinated substances and limited usage of membrane chromatography in large scale manufacturing may hamper the growth of the market.

Membrane Chromatography Market Trends

To know about the assumptions considered for the study, Request for Free Sample Report

Attractive Opportunities in the Membrane Chromatography Market

Membrane Chromatography Market Dynamics

DRIVER: Increasing biopharmaceutical R&D

In recent years, companies are significantly investing in biopharmaceutical research & development (R&D) in order to cater to the increasing demand for biopharmaceuticals. Globally, the demand for biopharmaceuticals is increasing due to a significant rise in the number of chronic illnesses, such as cancer, diabetes, and neurological and cardiovascular conditions, worldwide. The growing R&D expenditure by biopharmaceutical companies is accelerating the growth of the market. For instance, according to AseBio, in 2022, R&D investments by biotech companies in Spain increased by 16% to reach USD 1,093.8 million (EUR 1,038 million).

RESTRAINT: Limited usage of membrane chromatography products in large scale manufacturing

Despite various advantages of membrane chromatography, such as high purity and productivity, its adoption continues to be slow in large-scale operations. This is primarily due to the challenges associated with scaling up membrane chromatography processes to meet the demands of large-scale manufacturing. Additionally, the technical issues associated with membrane chromatography such as membrane degradation and membrane fouling limit its application in large-scale manufacturing. Moreover, traditional column chromatography is a well-established technology in the bioprocessing industry. Thus, replacing conventional column chromatography technologies after making significant investments is challenging for end users. Also, factors such as the risk of disruption of the whole process, alteration in the purity and quality of the final product, and financial losses due to failure, hamper the adoption of membrane chromatography products in large-scale manufacturing. Thus, the limited use of membrane chromatography products in large-scale manufacturing is restraining the growth of the market.

OPPORTUNITY: Shift towards single-use technologies

Single-use membrane chromatography systems offer several advantages, including reduced risk of cross-contamination, faster turnaround times, and lower capital investment. The adoption of single-use technologies in bioprocessing is expected to grow, driven by the demand for cost-effective and flexible solutions. Companies are focusing on the adoption of single-use technologies through collaborations or partnerships for effective downstream purification processes. For instance, in December 2022, W. L. Gore & Associates, Inc. collaborated with AGC Biologics to improve downstream purification processes through increased productivity of the Protein A step, enabling a full single-use downstream process. The collaboration includes the family of GORE Protein Capture Devices with Protein A, which improves productivity in Protein A affinity purification and provides high binding capacity.

CHALLENGE: Presence of alternative techniques to chromatography

Precipitation, high-resolution ultrafiltration, crystallization, high-pressure refolding, charged ultra-filtration membranes, protein crystallization, capillary electrophoresis, aqueous two-phase extraction, and three-phase partitioning are some of the prominent techniques that are available as alternatives to chromatography. Alternative techniques such as protein crystallization, capillary electrophoresis, and aqueous two-phase extraction require fewer steps and a large volume of antibodies can be separated into a single step. This helps to reduce the manufacturing costs and helps to increase the manufacturing volume. Such benefits provided by alternative techniques are likely to hamper the growth of the market.

Global Membrane Chromatography Industry Ecosystem Analysis

The market ecosystem comprises raw material suppliers, membrane chromatography product manufacturers, and end users such as pharmaceutical and biopharmaceutical companies, CROs and CDMOs, and academic and research institutes. Membrane chromatography product products manufacturers provide syringe filters, filter plates, capsule, cassettes, cartridges, membrane sheets, and spin column.

The flow-through membrane chromatography segment dominated the membrane chromatography industry in 2023.

Based on technique, the membrane chromatography market is segmented into flow-through membrane chromatography and bind-elute membrane chromatography. In 2023, the flow-through membrane chromatography segment dominated the market owing to the focus on the development of biologics such as monoclonal antibodies. Moreover, the rising demand for an efficient mode of operation for chromatography is propelling the segment's growth in the market.

The pharmaceutical & biopharmaceutical companies segment dominated the membrane chromatography industry in 2023.

Based on the end user, the membrane chromatography market is segmented into pharmaceutical & biopharmaceutical companies, CROs and CDMOs, and academic and research institutes. In 2023, the pharmaceutical & biopharmaceutical companies segment held the largest market share in the global market owing to demand for biotherapeutics. Additionally, rising research and development spending for the advancement of the biopharmaceutical products is promoting segment growth in the market.

North America dominated the membrane chromatography industry in 2023.

To know about the assumptions considered for the study, download the pdf brochure

The global membrane chromatography market is segmented into six major regions—North America, Europe, the Asia Pacific, Latin America, Middle East, and Africa. North America accounted for the largest share of market in 2023, followed by Europe and the Asia Pacific. Factors such as increasing development and manufacturing of biopharmaceuticals, significant investments in R&D activities, and presence of a well-established healthcare sector are responsible for the largest share of North America region in market.

Key players in the membrane chromatography market include Danaher Corporation (US), Sartorius AG (Germany), Merck KGaA (Germany), Thermo Fisher Scientific Inc. (US), 3M (US), Donaldson Company, Inc. (US), Cole-Parmer Instrument Company, LLC. (US), Restek Corporation (US), Agilent Technologies, Inc. (US), Bio-Rad Laboratories, Inc. (US), Shimadzu Corporation (Japan), W. L. Gore & Associates, Inc. (US), MACHEREY-NAGEL GmbH & Co. KG (Germany), Microsolv (US), Cobetter (China), Regis Technologies Inc. (US), Nupore Filtration Systems (India), Sterlitech Corporation (US), Microlab Scientific Co., Ltd (China), Nantong Filterbio Membrane Co.,Ltd. (China), Hahnemühle FineArt GmbH (Germany), BIOCOMMA LIMITED (China), Clinivex (Canada), Greyhound Chromatography and Allied Chemicals Ltd (UK), Membrane Solutions (China).

Scope of the Membrane Chromatography Industry

This report categorizes the membrane chromatography market to forecast revenue and analyze trends in each of the following submarkets:

By Product

• Capsules, Cassettes and Cartridges
• Syringe Filters
• Filter Plates
• Spin Columns
• Membrane Disc and Sheets
• Other consumables & Accessories

By Technique

• Ion Exchange Membrane Chromatography
  • Anion Exchange Membrane Chromatography
  • Cation Exchange Membrane Chromatography
• Affinity Membrane Chromatography
• Hydrophobic Interaction Membrane Chromatography

By Operation Mode

• Flow-Through Membrane Chromatography
• Bind-Elute Membrane Chromatography

By Membrane Material

• Polyethersulfone (PES)
• Cellulose
• Hydrogel
• Other Membrane Material

By End User

• Pharmaceutical & Biopharmaceutical Companies
• CROs and CDMOs
• Academic and Research Institutes

By Region

• North America
  • US
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Rest of Europe (RoE)
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific (RoAPAC)
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America (RoLATAM)
• Middle East
  • GCC Countries
    • Saudi Arabia (KSA)
    • United Arab Emirates (UAE)
    • Rest of GCC Countries (RoGCC)
  • Rest of Middle East (RoME)
• Africa

Recent Developments of The Membrane Chromatography Industry:

• In February 2024, Thermo Fisher Scientific Inc. opened a new sterile drug facility in Singapore to deliver new medicines and vaccines in the Asia Pacific market. The strategic investment complements new research capabilities at Thermo Fisher Scientific’s Customer Experience Center and Bioprocess Design Center. The Customer Experience Center includes 250 products across diverse fields, including molecular biology, genetic analysis sequencing, chromatography mass spectrometry, and cell therapy.
• In January 2023, Agilent Technologies expanded its state-of-the-art manufacturing capacity of nucleic acid-based therapeutics. The company invested USD 725 million for this expansion.
• In February 2022, Sartorius AG acquired Novasep’s chromatography division. The portfolio acquired comprises chromatography systems primarily suited for smaller biomolecules, such as oligonucleotides, peptides, and insulin, as well as innovative systems for continuous manufacturing of biologics. The acquisition aims to generate additional non-organic sales revenue for Sartorius AG.
• In June 2021, 3M launched the 3M Harvest RC clarifier to deliver a single-stage purification solution for recombinant protein therapeutic manufacturing.

Frequently Asked Questions (FAQ):

To speak to our analyst for a discussion on the above findings, click Speak to Analyst