ACL Graft Market: Growth, Size, Share, and Trends

Market Growth Outlook Summary

The global ACL graft market growth forecasted to transform from $0.12 billion in 2024 to $0.18 billion by 2029, driven by a CAGR of 7.2%. The market growth is primarily driven by the increasing age-related orthopedic complications, including ACL injuries, along with the growing geriatric population. Increased healthcare expenditure and the expansion of healthcare facilities globally are significant opportunities for market players. In addition, government policies that support healthcare funding and prioritize orthopedic treatments are facilitating access to ACL surgeries, which is driving demand for ACL grafts.

Attractive Opportunities in ACL Graft Market

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ACL Graft Market Dynamics

DRIVER: GROWING AGING POPULATION THAT IS MORE SUSCEPTIBLE TO ORTHOPEDIC COMPLICATIONS

The increasing incidences of knee injuries, including ACL injuries among the growing geriatric population, are one of the major driving factors of the ACL graft market. The rising number of physically active individuals aged 50 and above globally has resulted in an increased incidence of ACL tears within this demographic. The Centers for Disease Control and Prevention (CDC) has estimated that over 14 million older individuals in the US are at risk of sustaining these injuries annually. Falls are the primary cause of injuries and deaths among the elderly population, posing a significant public health concern as the second leading cause of fatal injuries globally. In 2022, adults aged 65 and above experienced over 3,000 fatal falls each month, resulting in 40,923 fatal fall injuries.

The increasing demand for ACL reconstruction procedures among the geriatric population highlights the crucial need for ACL grafts in this demographic segment. According to WHO, the number of people aged 60 and above is projected to double, reaching 2.1 billion by 2050. Therefore, the need for ACL reconstruction surgeries is expected to rise due to a projected rise in orthopedic injuries associated with sports among adults 65 years of age and above.

RESTRAINT: RISKS ASSOCIATED WITH ACL GRAFT SURGERY

Infection, graft failure, persistent pain, and knee stiffness are some of the potential risks associated with ACL graft surgery. Numbness is a common side effect that might happen in the leg, foot, or outside upper leg close to the surgery site. Instability is another risk, affecting 5% to 10% of patients due to stretching the reconstructed tendon. Some individuals experience knee stiffness or loss of mobility caused by excess scar tissue, potentially requiring further surgical intervention or manipulation under anesthesia. Postoperative knee pain, including discomfort at the front of the knee, behind the kneecap, or while kneeling, is also frequently reported.

Allografts may present unique risks for younger people, particularly those under the age of 30. They have been frequently associated with an increased risk of early graft failure in this age range as a result of the recipient's immune system rejecting the cadaveric tissue. An inflammatory response and eventual graft failure may result from the body's immune system targeting and rejecting the graft. The risk factors related to ACL graft procedures are impeding the expansion of the market.

OPPORTUNITY: EXPANSION OF HEALTHCARE FACILITIES AND INCREASED HEALTHCARE EXPENDITURE

The need for ACL grafts is expected to rise significantly due to the expansion of healthcare facilities and rising healthcare expenditure. The need for essential surgical supplies, including ACL grafts, is growing in tandem with the establishment of new hospitals, ambulatory surgery centers, and emergency care facilities. There is an increasing demand for high-quality ACL grafts driven by the adoption of advanced technologies in healthcare infrastructure and enhanced surgical capabilities.

The number of hospitals and surgical centers is increasing in developed as well as emerging economies. The demand for ACL grafts is high in newly established surgical centers and hospitals due to the growing patient population base and the rising number of surgical procedures such as knee replacements.

The American Hospital Association (AHA) 2024 reports that there are 6,120 hospitals in the US. Also, according to the Office for National Statistics, in 2022, the net capital expenditure of the UK on healthcare was USD 12.26 billion, reaching its highest level since 2009. Therefore, the rising number of healthcare facilities, including hospitals, along with increased investments in healthcare systems and the growing demand for surgeries and medical interventions, are creating opportunities for the growth of the ACL graft market.

CHALLENGE: DISCREPANCIES IN AVAILABILITY OF INSURANCE FOR ACL SURGERY

The inconsistency in insurance coverage for ACL surgeries presents a substantial challenge for the ACL graft market. Variations in insurance policies can result in uneven access to essential surgical interventions, impacting patient results and affecting the demand for ACL grafts. Areas or individuals with restricted insurance coverage may encounter financial obstacles, potentially resulting in postponed or avoided surgeries. This can affect market expansion and give rise to inequalities in the adoption of ACL grafts among diverse demographics and geographic areas.

According to an article (Out-of-pocket expenses for ACL reconstruction increased despite a decrease in reimbursement), ACL reconstruction surgery is among the highest-volume orthopedic procedures in the US, and it is witnessing high out-of-pocket expenses for patients as they are responsible for a larger share of their healthcare costs. Health insurance companies are cutting reimbursements and steering procedures towards more cost-effective facilities like ambulatory surgery centers. This change boosts insurers' profits but does not translate into cost savings for patients or healthcare providers. This pattern is adding to the growing financial strain on patients who require ACL reconstruction.

ACL Graft Market Ecosystem

The ACL graft market ecosystem includes manufacturers, distributors, and end users of ACL grafts. The key manufacturers of ACL grafts are LifeNet Health (US), MTF Biologics (US), RTI Surgical (US), Arthrex Inc. (US), and Parametrics Medical (US). Redline Surgical (US) and Biovault Technical (UK) are among the few distributors in the ACL graft market. Cleveland Clinic (US), Mount Sinai (US), Heidelberg University Hospital (Germany), and Mayo Clinic (US) are the end users in the market.

ABOVE 19 YEARS SEGMENT CAPTURED LARGEST MARKET SHARE IN 2023 AND IS PROJECTED TO REGISTER HIGHEST CAGR  DURING FORECAST PERIOD, BY AGE GROUP

Based on age group, the ACL graft market is segmented into 19 years and below and above 19 years. The above 19 years segment accounted for the largest share of the ACL graft market in 2023 and is projected to register the highest CAGR during the forecast period. This growth can be attributed to the increasing participation of older adults in sports and athletic activities. More individuals in this age group are engaging in physical activities that predispose them to ACL injuries. Furthermore, according to a BMC research article, sports are the most common cause of ACL injuries in patients under 30 years of age. Conversely, in individuals over 30 years of age, road traffic accidents (RTA) are a more frequent cause of ACL injuries.

Knee injuries often impose significant physical limitations on individuals over 40. As a result, ACLR surgery is becoming more common among middle-aged and older patients, reflecting the growing demand for ACL grafts in this demographic.

SPORTS INJURIES SEGMENT HELD LARGEST MARKET SHARE IN 2023 AND IS PROJECTED TO RECORD HIGHEST CAGR  DURING FORECAST PERIOD, BY INJURY TYPE

Based on injury type, the ACL graft market is segmented into sports injury and non-sports injury. The sports injuries segment had the largest share of the ACL graft market in 2023 and is projected to register the highest CAGR during the forecast period. ACL injuries are prevalent in sports that require abrupt stops, sharp changes in direction, or dynamic movements like jumping and landing, such as soccer, basketball, football, and downhill skiing. As participation in such sports has increased, ACL injuries are growing, which, in turn, influences the demand for ACL grafts positively.

In the sports injuries segment, football accounted for the largest share of the ACL transplant market in 2023. A wider public has been exposed to football due to the growth of youth and amateur competitions. Football players of all ages frequently sustain knee injuries, with ACL injuries being the most common. Players typically need ACL restoration due to the high incidence of ACL injuries; the most common method is a bone-patellar tendon-bone autograft.

IN 2023, NORTH AMERICA ACCOUNTED FOR LARGEST SHARE OF ACL GRAFT MARKET, FOLLOWED BY EUROPE

The six primary regions comprising the global ACL graft market are Latin America, the Middle East & Africa, Asia Pacific, Europe, North America, and the GCC countries. North America accounted for the largest share of the ACL graft market in 2023. The growth of the market in this region is due to the increase in sports-related injuries, rising awareness of advanced surgical techniques, the presence of key market players, and growing healthcare expenditures. North America had a population of 375.07 million in 2023, of which 66.75 million, or 18%, were 65 years of age or older. ACL injuries are among the disorders that are caused by this aging population's increased propensity for musculoskeletal problems and frequent falling or slipping, which is why the need for ACL grafts in reconstructive surgery is on the rise.

The primary drivers of the ACL graft market in the US are the aging population, which is more prone to orthopedic issues, the rising demand for ACL procedures, and the well-established healthcare system. Contact sports such as basketball, football, and soccer are popular in the US. Active participation in these sports activities increases the chance and severity of injuries, leading to a higher demand for ACL grafts in this country.

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Key Market Players

•  RTI Surgical (US)
•  AlloSource (US)
• MTF Biologics (US)
• LifeNet Health (US)

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Scope of the Report

This research report categorizes the ACL graft market into the following segments and subsegments:

Regional Split

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
• GCC Countries

ACL graft market, by type of ACL surgery

• Primary ACL Reconstruction
• ACL Revision

ACL graft market, by age group

• 19 years and below
• Above 19 years

ACL graft market, by gender

• Male
• Female

ACL graft market, by injury type

• Sports Injuries
• Non-sports Injuries

ACL graft market, by end user

• Hospitals & Ambulatory Surgery Centers
• Specialty Clinics

RECENT DEVELOPMENTS

• In July 2022, AlloSource (US) added quadricep tendons to its AlloConnex line of tendons, ligaments, and fascia. AlloSource's AlloConnex quadricep tendon is a preferred option for cruciate ligament procedures.

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