Spine Biologics Market by Product Type (Bone Graft, Bone Graft Substitute, Platelet Rich Plasma, BMAC), Surgery Type (Anterior Cervical Discectomy and Fusion, Posterior Lumbar Interbody Fusion), End User, and Geography - Global Forecast to 2020
Spinal biologics encompass materials that can be utilized in case of bone fusion surgery, spinal cord injury, and degenerative disk disease. Ten years ago, the spine treatment market constituted 75% traditional rods and plates made of metals and 25% biologics. However, since metals are inert materials, they did not stimulate the bone regeneration process. On the other hand, biological materials are proteins that can attract and stimulate cells, promote fusion, and help in the bone healing process. . The global spine biologics market is expected to reach $2.4 Billion by 2020, at a CAGR of 4.4% during the forecast period from 2015 to 2020.
The global market was valued at $1.90 Billion in 2014 and is expected to reach $2.4 Billion by 2020, at a CAGR of 4.4% from 2015-2020.
By product type, the spine biologics market is categorized into four types, namely, bone graft substitutes, bone grafts, platelet-rich plasma (PRP), and bone marrow aspirate concentrate therapy. In 2014, the bone graft substitutes segment contributed the largest share of 84.1% to the global market.
By surgery type, the market is segmented into: anterior cervical discectomy and fusion (ACDF), transforaminal lumbar interbody fusion (TLIF), anterior lumbar interbody fusion (ALIF), lateral lumbar interbody fusion (LLIF), and other surgeries. The ACDF segment contributed the largest share to the global spine biologics market in 2014, followed by the transforaminal lumbar interbody fusion (TLIF) segment.
The global spine biologics market has been categorized by regions into North America, Europe, Asia-Pacific, and the Rest of the World. North America is the most dominant region in the global market, followed by Europe. Bone graft substitute segment dominated the North American spine biologics market.
Some of the major players in the spine biologics market are Medtronic Inc. (U.S.), DePuy Synthes Companies (U.S.), Zimmer Holding Inc. (U.S.), Nuvasive Inc. (U.S.), Stryker Corporation (U.S.), Orthofix international N.V. (U.S.), K2M Inc. (U.S.), Exactech Inc. (U.S.), Wright Medical Technology Inc. (U.S.), and others.
Key stakeholders of this market include spine biologics manufacturing companies, medical device distributors, healthcare institutions (hospitals, medical schools and governing bodies), health insurance players, research and consulting firms, and regulatory authorities (FDA).
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This report categorizes the global market for spine biologics on the basis of Product type, Surgery type, and region.
Market Segmentation, by Product Type:
Based on type, the global spine biologics market is segmented into Bone Graft Substitutes, Bone Grafts, Platelet Rich Plasma (PRP), and Bone Marrow Aspirate Concentrate (BMAC) Therapy.
Market Segmentation, by Surgery type:
Based on surgery type, the global spine biologics market is classified into Anterior Cervical Discectomy and Fusion (ACDF), Transforamenal Lumbar Interbody Fusion (TLIF), Anterior Lumbar Interbody Fusion (ALIF), Lateral Lumbar Interbody Fusion (LLIF), and Other Surgeries.
Market Segmentation, by Region:
The regional analysis covers North America, Europe, Asia-Pacific, and RoW.
Customization Options : Spine Biologics Market
Along with market data, customize the MarketsandMarkets study to meet your company’s specific needs. Customize to get a comprehensive summary of the industry standards and a detailed analysis of the following parameters:
Product Analysis
- Usage pattern (in-depth trend analysis) of products (segment-wise)
- Product matrix, which gives a detailed comparison of product portfolio of each company, mapped at country- and sub segment-level
Spine Surgeons/ Doctors Perception Analysis
- Fast turn-around analysis of spine surgeons and doctors responses to market events and trends
- Spine surgeons and Physicians opinions about products from different companies
- Region-specific spine surgeons qualitative inputs on spine biologics
Regulatory Framework
- Listing the regulatory issues of major countries if they are adversely affecting the business/market/industry
- Studying the reimbursements and its related impact offered by the government
Competitive Intelligence
- Market share of region-specific players in the market
- Crucial developments and strategies of the key companies inculcated in their portfolio
The report on global spinal biologics market analyzes and segments the market on the basis of product, surgery type, and region. It analyzes the competitive developments, such as alliances, joint ventures, and mergers & acquisitions in the global spine biologics market. This market is also analyzed with an explicit focus on the high-growth applications and fastest-growing market segments.
The spine biologics devices are used in spine surgery as lieu allografts as well as a support for bones in and around the spinal region. These devices offer numerous benefits over materials such as pedicle rods and screws that are used in spine fusion. Since metals are inert in nature, they do not stimulate or activate cellular growth or alter cellular functions such as natural healing. Spine biologics, on the other hand, activate cellular growth by stimulating spine fusion. The driving forces for global spinal biologics market include rising incidence of spinal disorders, rising healthcare expenditure in developing nations owing to growing income levels, rising obesity cases, awareness on the newly developed spine treatment techniques and devices, technological advancements, and rising demand of minimally invasive spine surgeries. The major restraints for this market include lack of expertise, lack of patient awareness, cost of surgery, and unfavourable reimbursement scenario.
Traditionally, allografts were considered as a gold standard for replenishment of the spinal bones. However, drawbacks such as donor site complications, high surgical cost, lengthy surgical surgeries, and longer recovery time resulted in a shift from allograft bones to other biological alternatives, such as bone morphogenetic proteins (BMP), demineralized bone matrix (DBM), and bone substitutes. BMPs stimulate the process of bone growth and spinal fusion. They offer advantages such as minimal postoperative pain, shorter hospital stays, faster recovery, in addition to eliminating the need of harvesting bone from patient. Currently, clinical investigation in order to increase its application in spine degenerative disc surgery is in process.
The global market was dominated by North America in 2014, followed by Europe, Asia-Pacific, and Rest of the World (RoW). North America is expected to continue to lead the spine biologics market in coming years, followed by Europe. The market in Asia-Pacific is projected to grow at the highest CAGR of 7.6% during the forecast period from 2015 to 2020. The growth in this region is expected to be driven by rising aging population, increasing per capita healthcare expenditure, and rising demand from China and India due to their respective large population base.
The global spine biologics market was valued at $1.9 billion in 2014. The North American market contributed the largest share to the global market in 2014 with the U.S. dominating the North America market.
Some of the major players in the spine biologics market are Medtronic Inc. (U.S.), Depuy Synthes Companies (U.S.), Zimmer Holding Inc. (U.S.), Nuvasive Inc. (U.S.), Stryker Corporation (U.S.), Orthofix International N.V. (U.S.), K2M Inc. (U.S.), Exactech Inc. (U.S.), Wright Medical Technology Inc. (U.S.), and others.
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Table of Contents
1 Introduction (Page No. - 11)
1.1 Objectives of the Study
1.2 Market Segmentation & Coverage
1.3 Stakeholders
2 Research Methodology (Page No. - 13)
2.1 Integrated Ecosystem of Spine Biologics Market
2.2 Arriving at the Spine Biologics Market Size
2.2.1 Top-Down Approach
2.2.2 Bottom-Up Approach
2.2.3 Macro Indicator-Based Approach
2.3 Assumptions
3 Executive Summary (Page No. - 20)
4 Market Overview (Page No. - 22)
4.1 Introduction
4.2 Market Drivers and Inhibitors
5 Spine Biologics Market, By Surgery Type (Page No. - 25)
5.1 Introduction
5.2 Anterior Cervical Discectomy and Fusion (ACDF)
5.3 Posterior Lumbar Interbody Fusion (PLIF)
5.4 Transforaminal Lumbar Interbody Fusion (TLIF)
5.5 Anterior Lumbar Interbody Fusion (ALIF)
5.6 Lateral Lumbar Interbody Fusion (LLIF)
5.7 Others
6 Spine Biologics Market By Product Type (Page No. - 37)
6.1 Introduction
6.2 Bone Graft
6.2.1 Autograft
6.2.2 Allograft
6.3 Bone Graft Substitutes
6.3.1 Synthetic Bone Grafts
6.3.2 Demineralized Bone Matrix (DBM)
6.3.3 Bone Morphogenetic Proteins (BMP)
6.4 Platelet Rich Plasma (PRP)
6.5 Bone Marrow Aspirate (BMAC) Therapy
7 Spine Biologics Market, By Geography (Page No. - 52)
7.1 Introduction
7.2 North America
7.2.1 Spine Biologics Market, By Country
7.2.2 Market, By Product Type
7.2.3 Bone Graft Substitutes Market, By Product Type
7.2.4 Market, By Surgery Type
7.3 Europe
7.3.1 Market, By Country
7.3.2 Market, By Product Type
7.3.3 Bone Graft Substitutes Market, By Product Type
7.3.4 Market, By Surgery Type
7.4 Asia Pacific
7.4.1 Market, By Country
7.4.2 Market, By Product Type
7.4.3 Bone Graft Substitutes Market, By Product Type
7.4.4 Market, By Surgery Type
8 Competitive Landscape (Page No. - 69)
8.1 Company Share Analysis
8.2 Product Launches
8.3 Mergers and Acquisitions
8.4 Collaborations, Joint Agreements & Expansions, Partnerships
8.5 Approvals, Alliances, Relocation & Licensing
9 Company Profiles (Page No. - 74)
(Overview, Financials, Products & Services, Strategy, and Developments)*
9.1 Zimmer Holding, Inc.
9.2 Depuy Synthes
9.3 Medtronic, Inc. (U.S.)
9.4 Nuvasive, Inc.
9.5 Stryker Corporation
9.6 Orthofix International N.V.
9.7 K2M, Inc.
9.8 Exactech, Inc.
9.9 Wright Medical Technology, Inc.
9.10 Nutech
9.11 Arthrex, Inc.
9.12 X-Spine Systems, Inc. (Bacterin International Holdings, Inc.)
9.13 DR PRP USA LLC
*Details on Overview, Financials, Product & Services, Strategy, and Developments Might Not Be Captured in Case of Unlisted Company
10 Appendix (Page No. - 99)
10.1 Introducing RT: Real-Time Market Intelligence
10.2 Customization Options
10.2.1 Product Analysis
10.2.2 Spine Surgeons/ Doctors Perception Analysis
10.2.3 Regulatory Framework
10.2.4 Competitive Intelligence
10.3 Related Reports
List of Tables (55 Tables)
Table 1 Spine Biologics Market: Healthcare Expenditure, By Geography, 2014 (USD Million)
Table 2 Spine Biologics Market, By Product Type, 2013-2020 (USD Million)
Table 3 Spine Biologics Market, By Surgery Type, 2013-2020 (USD Million)
Table 4 Spine Biologics Market, By Geography, 2013-2020 (USD Million)
Table 5 Drivers and Inhibitors
Table 6 Spine Biologics Market, By Surgery Type, 2013-2020 (USD Million)
Table 7 Spine Biologics Market in Anterior Cervical Discectomy and Fusion (ACDF) Surgery, By Product Type, 2013-2020 (USD Million)
Table 8 Spine Biologics Market in Anterior Cervical Discectomy and Fusion (ACDF) Surgery, By Geography, 2013-2020 (USD Million)
Table 9 Spine Biologics Market in Transforaminal Lumbar Interbody Fusion (TLIF) Surgery, By Product Type, 2013-2020 (USD Million)
Table 10 Spine Biologics Market in Transforaminal Lumbar Interbody Fusion (TLIF) Surgery, By Geography, 2013-2020 (USD Million)
Table 11 Spine Biologics Market in Anterior Lumbar Interbody Fusion (ALIF) Surgery, By Product Type, 2013-2020 (USD Million)
Table 12 Spine Biologics Market in Anterior Lumbar Interbody Fusion (ALIF) Surgery, By Geography, 2013-2020 (USD Million)
Table 13 Spine Biologics Market in Lateral Lumbar Interbody Fusion (LLIF) Surgery, By Product Type, 2013-2020 (USD Million)
Table 14 Spine Biologics Market in Lateral Lumbar Interbody Fusion (LLIF) Surgery, By Geography, 2013-2020 (USD Million)
Table 15 Market Value By Product Type, 2013-2020 (USD Million)
Table 16 Bone Grafts Market Value By Surgery Type, 2013-2020 (USD Million)
Table 17 Bone Grafts Market Value By Geography, 2013-2020 (USD Million)
Table 18 Bone Graft Substitutes Market Value By Product Type, 2013-2020 (USD Million)
Table 19 Synthetic Bone Grafts Market Value By Surgery Type, 2013-2020 (USD Million)
Table 20 Synthetic Bone Grafts Market Value By Geography, 2013-2020 (USD Million)
Table 21 Demineralized Bone Matrix (DBM) Market Value By Surgery Type, 2013-2020 (USD Million)
Table 22 Demineralized Bone Matrix (DBM) Market Value By Geography, 2013-2020 (USD Million)
Table 23 Bone Morphogenetic Protein (BMP) Market Value By Surgery Type, 2013-2020 (USD Million)
Table 24 Bone Morphogenetic Protein (BMP) Market Value By Geography, 2013-2020 (USD Million)
Table 25 Platelet Rich Plasma (PRP) Market Value By Geography, 2013-2020 (USD Million)
Table 26 Bone Marrow Aspirate Concentrate (BMAC) Therapy Market Value By Geography, 2013-2020 (USD Million)
Table 27 Spine Biologics Market Size, By Geography, 2013 – 2020 (USD Million)
Table 28 North America: Market, By Country, 2013-2020 (USD Million)
Table 29 North America: Market, By Product Type, 2013-2020 (USD Million)
Table 30 North America: Bone Graft Substitutes Market, By Product Type, 2013-2020 (USD Million)
Table 31 North America: Market, By Surgery Type, 2013-2020 (USD Million)
Table 32 Europe: Market, By Country, 2013-2020 (USD Million)
Table 33 Europe: Market, By Product Type, 2013-2020 (USD Million)
Table 34 Europe: Bone Graft Substitutes Market, By Product Type, 2013-2020 (USD Million)
Table 35 Europe: Market, By Surgery Type, 2013-2020 (USD Million)
Table 36 Asia Pacific: Market, By Country, 2013-2020 (USD Million)
Table 37 Asia Pacific: Market, By Product Type, 2013-2020 (USD Million)
Table 38 Asia Pacific: Bone Graft Substitutes Market, By Product Type, 2013-2020 (USD Million)
Table 39 Asia Pacific: Market, By Surgery Type, 2013-2020 (USD Million)
Table 40 Company Share Analysis, 2014
Table 41 Product Launches
Table 42 Mergers and Acquisitions
Table 43 Collaborations, Joint Agreements & Expansions
Table 44 Approvals, Alliances, Relocation & Licensing
Table 45 Zimmer Holding, Inc.: Revenue, By Business Segment, 2009-2014 (USD Million)
Table 46 Johnson & Johnson Ltd.: Revenue, By Business Segment, 2011-2014 (USD Million)
Table 47 Medtronic, Inc. : Revenue, By Business Segment, 2009-2013 (USD Million)
Table 48 Nuvasive, Inc.: Revenue, By Product Type, 2010-2014 (USD Million)
Table 49 Stryker Corporation.: Revenue, By Business Segment, 2010-2014 (USD Million)
Table 50 Orthofix Holdings, Inc.: Revenue, By Business Segment, 2012-2014 (USD Million)
Table 51 K2M Inc.: Revenue, 2011-2014 (USD Million)
Table 52 Exactech, Inc.: Revenue, By Business Segment, 2010-2014 (USD Million)
Table 53 Exactech, Inc.: Key Financials, By Geography, 2010-2014 (USD Million)
Table 54 Wright Medical Technology, Inc.: Revenue, By Business Segment, 2011-2013 (USD Million)
Table 55 Wright Medical Technology, Inc.: Revenue, By Geography, 2011-2013 (USD Million)
List of Figures (54 Figures)
Figure 1 Segmentation & Coverage
Figure 2 Integrated Ecosystem
Figure 3 Research Methodology
Figure 4 Top-Down Approach
Figure 5 Bottom-Up Approach
Figure 6 Macro Indicator-Based Approach (2014)
Figure 7 Market Snapshot
Figure 8 Market, By Surgery Type, 2014 & 2020 (USD Million)
Figure 9 Market in Anterior Cervical Discectomy and Fusion (ACDF) Surgery, By Product Type, 2015 & 2020 (USD Million)
Figure 10 Market in Anterior Cervical Discectomy and Fusion (ACDF) Surgery, By Geography, 2015 & 2020 (USD Million)
Figure 11 Spine Biologics Market in Transforaminal Lumbar Interbody Fusion (TLIF) Surgery, By Product Type, 2015 & 2020 (USD Million)
Figure 12 Spine Biologics Market in Transforaminal Lumbar Interbody Fusion (TLIF) Surgery, By Geography, 2015 & 2020 (USD Million)
Figure 13 Spine Biologics Market in Anterior Lumbar Interbody Fusion (ALIF) Surgery, By Product Type, 2015 & 2020 (USD Million)
Figure 14 Spine Biologics Market in Anterior Lumbar Interbody Fusion (ALIF) Surgery, By Geography, 2015 & 2020 (USD Million)
Figure 15 Spine Biologics Market in Lateral Lumbar Interbody Fusion (LLIF) Surgery, By Product Type, 2015 & 2020 (USD Million)
Figure 16 Spine Biologics Market in Lateral Lumbar Interbody Fusion (LLIF) Surgery, By Geography, 2015 & 2020 (USD Million)
Figure 17 Spine Biologics Market Value, By Product Type, 2014 & 2020 (USD Million)
Figure 18 Bone Grafts Market Value, By Surgery Type, 2015 & 2020 (USD Million)
Figure 19 Spine Grafts Market Value, By Geography, 2015 & 2020 (USD Million)
Figure 20 Bone Graft Substitutes Market Value, By Product Type, 2014 & 2020 (USD Million)
Figure 21 Synthetic Bone Grafts Market Value, By Surgery Type, 2015 & 2020 (USD Million)
Figure 22 Synthetic Bone Grafts Market Value, By Geography, 2015 & 2020 (USD Million)
Figure 23 Demineralized Bone Matrix (DBM) Market Value, By Surgery Type, 2015 & 2020 (USD Million)
Figure 24 Demineralized Bone Matrix (DBM) Market Value, By Geography, 2015 & 2020 (USD Million)
Figure 25 Bone Morphogenetic Protein (BMP) Market Value, By Surgery Type, 2015 & 2020 (USD Million)
Figure 26 Bone Morphogenetic Protein (BMP) Market Value, By Geography, 2015 & 2020 (USD Million)
Figure 27 Platelet Rich Plasma (PRP) Market Value, By Geography, 2015 & 2020 (USD Million)
Figure 28 Bone Marrow Aspirate Concentrate (BMAC) Therapy Market Value, By Geography, 2015 & 2020 (USD Million)
Figure 29 Spine Biologics Market: Growth Analysis, By Geography, 2014 – 2020 (USD Million)
Figure 30 North America: Market Overview, 2014 & 2020 (%)
Figure 31 North America: Market, By Country, 2015 & 2020 (USD Million)
Figure 32 North America: Market, By Product Type, 2015 & 2020 (USD Million)
Figure 33 North America: Bone Graft Substitutes Market, By Product Type, 2015 & 2020 (USD Million)
Figure 34 North America: Spine Biologics Market, By Surgery Type, 2015 & 2020 (USD Million)
Figure 35 Europe: Spine Biologics Market Overview, 2014 & 2020 (%)
Figure 36 Europe: Spine Biologics Market, By Country, 2015 & 2020 (USD Million)
Figure 37 Europe: Spine Biologics Market, By Product Type, 2015 & 2020 (USD Million)
Figure 38 Europe: Bone Graft Substitutes Market, By Product Type, 2015 & 2020 (USD Million)
Figure 39 Europe: Spine Biologics Market, By Surgery Type, 2015 & 2020 (USD Million)
Figure 40 Asia Pacific: Spine Biologics Market Overview, 2014 & 2020 (%)
Figure 41 Asia Pacific: Spine Biologics Market, By Country, 2015 & 2020 (USD Million)
Figure 42 Asia Pacific: Spine Biologics Market, By Product Type, 2015 & 2020 (USD Million)
Figure 43 Asia Pacific: Bone Graft Substitutes Market, By Product Type, 2015 & 2020 (USD Million)
Figure 44 Asia Pacific: Spine Biologics Market, By Surgery Type, 2015 & 2020 (USD Million)
Figure 45 Spine Biologics Market: Company Share Analysis, 2014 (%)
Figure 46 Zimmer Holding, Inc.: Revenue Mix, 2014 (%)
Figure 47 Johnson & Johnson Ltd.: Business Revenue Mix, 2014 (%)
Figure 48 Medtronic, Inc.: Revenue Mix, 2013 (%)
Figure 49 Nuvasive Inc.: Revenue Mix, 2014 (%)
Figure 50 Stryker Corporation: Revenue Mix, 2014 (%)
Figure 51 Orthofix International N.V.: Business Revenue Mix, 2014 (%)
Figure 52 K2M, Inc.: Geographic Revenue Mix, 2014 (%)
Figure 53 Exactech, Inc.: Revenue Mix, 2014 (%)
Figure 54 Wright Medical Technology, Inc.: Revenue Mix, 2014 (%)
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