Bone Cement & Glue Market: Growth, Size, Share, and Trends

Market Growth Outlook Summary

The global bone cement & glue market, valued at US$1,549 million in 2022, is forecasted to grow at a robust CAGR of 6.5%, reaching US$1,644 million in 2023 and an impressive US$2,248 million by 2028. The growth of this market is majorly driven by growing number of road traffic accidents and rising number of surgical procedures However, extensive clinical data requirements for launching new bone cements may restrain the growth of this market.

Attractive Opportunities in the Bone Cement & Glue Market

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Bone Cement & Glue Market Dynamics

DRIVER: Growing incidences of sports injuries

Globally, the incidence of sports injuries has increased over the last few years primarily due to the growing participation in sports as well as active participation in fitness activities (because of the growing focus on leading healthy lifestyles), Intensity and competitiveness, Insufficient recovery, and rest. Some of the major statistics in this regard have been mentioned below:

According to The Johns Hopkins University 2023, In the U.S., about 30 million children and teens participate in some form of organized sports, and more than 3.5 million injuries each year. Sports and recreational activities contribute to approximately 21% of all traumatic brain injuries among American children. Similarly, almost 50% of head injuries sustained in sports or recreational activities occur during bicycling, skateboarding, or skating incidents. More than 775,000 children, ages 14 and younger, are treated in hospital emergency rooms for sports-related injuries each year.

• In 2021, the United States, the National Athletic Trainers' Association (NATA) reports that an estimated 2 million high school athletes suffer sports-related injuries and 30,000 hospitalizations each year.
• According to the Centers for Disease Control and Prevention (CDC), approximately 8.6 million sports-related injuries occur each year, with more than 2.6 million of those injuries requiring medical attention. The most reported injuries are sprains, strains, fractures, and contusions. In addition, traumatic brain injuries and concussions have become a major focus of research and prevention efforts.
• As per the New York CNN 2023, Pickleball is America’s fastest-growing sport and Pickleball injuries may cost Americans USD 377 million in health care costs this year which is driving up the cost burden.
• As per the Australian Institute of Health and Welfare 2023, Injuries related to physical activity cost USD 164 million in emergency departments and USD 600 million for admitted patients.
• As per The Athletic Media Company 2023, Big Five’ leagues in the 2021-22, European season, injury costs for clubs reached £513.23 million, (USD 547.86) a 29% rise compared to the previous campaign (2021).

Hip-, knee-, and shoulder-related injuries are the major sports injuries. These injuries often require the replacement of the affected joint with a synthetic (metal) implant (arthroplasty), supplemented with bone cement and bone graft substitutes. With the increasing participation in sports and subsequent growth in the incidence of sports injuries, the demand for bone cement and glue is expected to increase across the globe during the forecast period.

Restraints: High costs and extensive clinical data requirements for launching new bone cements

The development of bone cement is an extremely cost-intensive process. It takes significant investments in R&D to develop new products that effectively cater to market needs. The FDA approval process for surgical orthopedic cements is stringent and time-consuming, causing delays in bringing new bone cements to the market. The FDA demands more clinical data related to the safety and efficacy of the product, which results in tin additional R&D investments for companies. Despite the development of several advanced cements in the market, there is still a need for developing cost-effective bone cements with the appropriate clinical data required by regulatory authorities.

Owing to the abovementioned factors, many small firms and start-ups do not focus on launching new innovative products in the market. Such companies are pressured to reevaluate the timelines and budgets required in product development, which ultimately affects their market survival. Moreover, due to the presence of alternatives such as bone staples and orthopedic pins, the uptake of advanced bone cements is affected. This, in turn, is restraining the growth of the overall market.

Some of the prices of commercially available bone cements are as below:

DePuy SmartSet Bone Cement - SmartSet HV Bone Cement, 40G, High-Viscosity - USD 400-500, Spineplex - Bone Cement 20 g Twin Pack (One-Half Dose) – USD 700-800, Palacos Bone Mixing Cements by Heraeus Medica - USD 800-900

OPPORTUNITY: Rising awareness and demand for minimally invasive procedures

Minimally invasive surgeries offer benefits such as smaller incisions, reduced scarring, and faster recovery times. There is an increasing demand for minimally invasive orthopedic procedures, and bone cement and glue play a crucial role in these techniques. Opportunities exist for the development of specialized bone cement and glue products tailored for minimally invasive approaches. Minimally invasive procedures often result in reduced post-operative pain, shorter hospital stays, and faster rehabilitation compared to traditional open surgeries. This can lead to improved patient satisfaction and outcomes. The use of appropriate bone cement and glue products in these procedures contributes to the overall success and effectiveness of the treatment.

• As per the PubMed 2022, Ambulatory Minimally invasive surgeries MIS procedures showed an increasing trend across years, representing 16.9%, 17.4%, and 18%, respectively. Healthcare Cost and Utilization Project (HCUPNet) data revealed an increase in inpatient MIS cases from 529,811 (8.9%) in 1993 to 1,443,446 (20.7%) in 2014.
• As per the Intuitive Surgical Operations, Inc. 2023 (US), through more than 10 million surgeries, Intuitive has become a leader in surgical robotics, increasing the adoption of minimally invasive surgery.

Minimally invasive procedures can be cost-effective compared to traditional open surgeries. They may result in lower healthcare resource utilization, reduced hospitalization costs, and quicker return to daily activities and work. Bone cement and glue products that support minimally invasive approaches align with the cost-saving goals of healthcare systems and providers. For instance, As per the article published in musculoskeletal key 2020, health care costs were nearly 18% of the U.S. gross domestic product (GDP), with the cost of surgical care was approximately 7% of GDP. The patients with Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF), the mean length of postoperative hospital stay was 3 days. The mean total in-hospitalization cost for these patients was USD 23,000. Each 1-day reduction in the length of stay results in a direct cost savings of USD 1,500. On the other hand, patients with open-TLIF, the mean length of postoperative hospital stay was 4 days. The mean total in-hospitalization cost for these patients was USD 25,000.Hence, the rising awareness and demand for minimally invasive procedures have a positive impact on the bone cement and glue market.

CHALLENGE: Product-related complications.

While bone cement and glue products are generally safe and effective, like any medical intervention, they can be associated with certain complications. Here are some potential complications associated with bone cement and glue:

• Infection: Infection is a possible complication following the use of bone cement and glue. Although efforts are made to maintain a sterile surgical environment, there is still a risk of bacterial contamination during the procedure or post-operatively. Infection can lead to implant loosening, prolonged healing, and the need for additional treatments or surgeries.
• Allergic reactions: Some individuals may experience allergic reactions to components of bone cement or glue, such as methacrylate monomers. Allergic reactions can manifest as localized inflammation, skin rashes, or more severe systemic reactions. Careful evaluation of patient history and selection of appropriate materials can help mitigate the risk of allergic reactions.
• Cement leakage: During the application of bone cement, there is a possibility of cement leakage into surrounding tissues or blood vessels. Cement leakage can lead to complications such as nerve impingement, embolism (if cement enters the bloodstream), or tissue damage. Proper surgical technique and monitoring can help reduce the risk of cement leakage.
• Implant loosening: Although bone cement is used to secure implants, there is still a possibility of implant loosening over time. Factors contributing to implant loosening include improper technique, poor bone quality, excessive weight-bearing, or inadequate cement fixation. Implant loosening may require revision surgery to address the instability and ensure long-term implant function.
• Adverse tissue reactions: Some individuals may experience adverse tissue reactions to bone cement or glue. These reactions can manifest as chronic inflammation, granuloma formation, or hypersensitivity reactions. The incidence of such reactions is relatively rare, but they can result in discomfort, implant failure, or the need for further interventions.
• Thermal necrosis: During the polymerization process of bone cement, heat is generated, which can potentially cause thermal necrosis (tissue damage due to excessive heat) in surrounding tissues. This risk is mitigated by proper cement handling, cooling techniques, and careful monitoring during the procedure.

Likewise, some of the Potential disadvantages of antibiotic-loaded bone cement are as below

• Alteration in the mechanical and structural properties of the bone cement
• Antibiotic resistance
• Allergic reactions
• Systemic toxicity
• Cost implications

The Bone Cement segment is expected to account the largest shares during the forecast period.

Based on Type, the Bone Cement & Glue market is segmented into Bone Cement and Glue. The Bone Cement segment is expected to account the largest shares during the forecast period. The major factors contributing to the growth of this market are due it its wide applications, as Bone cement is widely used for in various orthopedic such as such as total hip arthroplasty (THA) and total knee arthroplasty (TKA), also to anchor prosthetic implants and trauma surgeries. Bone cement is a synthetic polymer-based material used primarily in joint replacement surgeries, while bone glue is a biological adhesive used to bond tissues and bones.

The PMMA (Polymethyl methacrylate Cement segment is projected to grow at the highest CAGR during the forecast period.

Based on Type, the Bone Cement market is segmented into PMMA (Polymethyl methacrylate Cement), CPC (Calcium Phosphate Cement), and GPC (Glass polyalkenoate cement). The PMMA (Polymethyl methacrylate Cement segment is projected to grow at the highest CAGR during the forecast period. The major factors contributing to the growth of this market are PMMA bone cements are widely used in various orthopedic procedures such as arthroplasty, kyphoplasty and vertebroplasty hence increasing demand of PMMA segment compared to other bone cements such as CPC and GPC.

The Natural bone glue segment is forecasted to grow at the highest CAGR during the forecast period.

Based on Type, the Bone Glue market is segmented into Natural bone glue and Synthetic bone glue. The Natural bone glue segment is forecasted to grow at the highest CAGR during. The major factors contributing to the growth of this market includes Natural bone glue’ Biocompatibility, Biodegradability, its ability to Reduced Foreign Body Response which can lead to faster healing and reduced inflammation around the adhesive site compared to synthetic materials.

The Antibiotic-loaded bone cement segment is anticipated to grow at the highest CAGR during the forecast period.

Based on Loading, the Bone Cement & Glue market is segmented into Antibiotic-loaded bone cement, and non-Antibiotic-loaded bone cement. The Antibiotic-loaded bone cement segment is anticipated to grow at the highest CAGR considering Antibiotic-loaded bone cement has been widely adopted in orthopedic surgeries due to its ability to provide localized antibiotic therapy, helping to prevent or treat infection in the surgical site. The addition of antibiotics such as gentamicin, vancomycin, and tobramycin to the bone cement allows for sustained release of the antibiotic agent over time, helping to reduce the risk of infection associated with orthopedic procedures.

The Arthroplasty segment is expected to dominate the market during the forecast period.

Based on the Application, the Bone Cement & Glue market is segmented into Arthroplasty (Total knee arthroplasty, Total hip arthroplasty, Total shoulder arthroplasty), kyphoplasty, Vertebroplasty and Other Applications. The Arthroplasty segment is expected to dominate the market during the forecast period due to the increasing number of knee, hip, and shoulder injuries, Increasing Prevalence of osteoarthritis, rising aging Population as people age, the wear and tear on their joints increase, and they may require joint replacement surgeries like total hip arthroplasty (THA) or total knee arthroplasty (TKA).

The Hospitals, & Ambulatory Surgical Centers is expected to dominate the market during the forecast period.

Based on the end user, the Bone Cement & Glue market is segmented into Hospitals, & Ambulatory Surgical Centers, and Clinics/Physician offices. The Hospitals, & Ambulatory Surgical Centers is expected to dominate the market during the forecast period due to the increasing number of orthopedic surgical procedures as patients with traumatic, surgical, receive specialized care from experts as an integral part of overall hospital care, as well as various cost-effective and convenient treatments provided by ASCs.

North America accounted for the largest share of the Bone Cement & Glue market.

Based on the region, the Bone Cement & Glue market is segmented into North America, Europe, Asia Pacific, and Rest of the World. In 2022, North America accounted for the largest share of the Bone Cement & Glue market. Growth in the North American market is mainly driven by the high prevalence of target diseases, increasing geriatric population, and rising awareness about advanced treatment options, the strong presence of key market players in this region. In addition, the presence of a well-established healthcare system and ongoing investments by hospitals to upgrade and expand their operating capabilities are other factors supporting the growth of the North American Bone Cement & Glue market.

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India registered the highest growth rate in Asia Pacific Bone cement & glue industry.

The APAC bone cement & glue market is segmented into Japan, China, India, and Rest of Apac. In 2022, India accounted for the highest growth rate of the Asian bone cement & glue market. The high growth rate of India can be attributed to the rising of a medical tourism in orthopedic surgery sector and the increasing geriatric population. An increase in the number of elderly people gives rise to various orthopedic and diseases which is highly susceptible to several procedures. Therefore, growth in this population segment will directly drive the demand for bone cement & glue products.

The Germany in European Bone cement & glue industry to witness the second highest growth rate during the forecast period.

The Europe bone cement & glue market is segmented into Germany, France, the UK, and the Rest of Europe. Germany is registered the highest growth rate during the forecast period. The major factors contributing to the growth of this market are the high prevalence ofold age population, rising in sport related injuries, orthopedic cases, increasing R&D activities, strategic developments by key players.

Some of the major players operating in this market are Stryker (US), Zimmer Biomet (US), Smith+Nephew. (UK), DePuy Synthes (a subsidiary of Johnson & Johnson - US) , Enovis  (US) , Artivion, Inc (US), Cardinal Health. (US), Medtronic (Ireland), Globus Medical (US), and Heraeus Holding (Germany).

Bone Cement & Glue Market Report Scope

This research report categorizes the Bone cement & glue market into the following segments and subsegments:

By Type (Bone Cement)

• PMMA Cement
• Calcium Phosphate Cement
• Glass polyalkenoate cement

By Type (Bone Glue)

• Natural bone glue
• Synthetic bone glue

By Loading

• Non-antibiotic-loaded bone cement
• Antibiotic-loaded bone cement

By Application

• Arthroplasty
• Total knee arthroplasty
• Total hip arthroplasty
• Total shoulder arthroplasty
• Kyphoplasty
• Vertebroplasty
• Other Applications

By End User

• Hospitals & Ambulatory Surgical Centers
• Other End Users

By Region

• North America
• Europe
• APAC
• Rest of the World

Recent Developments of Bone Cement & Glue Market

• In 2021, The company Smith & Nephew (UK) acquired the Extremity Orthopedics business of Integra Life Sciences to expand its shoulder, upper, and lower extremities product portfolio.
• In 2021, Zimmer Biomet (US) Completed the spinoff of spine and dental businesses into a new public company, ZimVie Inc. (“ZimVie”). The transaction was intended to benefit its stockholders by enhancing the focus of both Zimmer Biomet and ZimVie to meet the needs of patients and customers

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