Bone Cement & Glue Market

The global bone cement & glue market in terms of revenue was estimated to be worth $1,644 million in 2023 and is poised to reach $2,248 million by 2028, growing at a CAGR of 6.5% from 2023 to 2028. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. The growth of this market is majorly driven by the Rising Demand for Minimally Invasive Surgeries with robotic assistance and Growing healthcare sector and Increasing Incidence of Orthopedic Conditions. However, Challenges associated with Variability of pathogen resistance may threat the growth of this market.

Attractive Opportunities in the Bone Cement & Glue Market

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Recession Impact on the Bone Cement & Glue Market

The impact of a global recession can vary across different regions and countries. Economic conditions, healthcare systems, and regulatory environments differ worldwide, and the severity and duration of the recession will also influence the extent of its impact on the bone cement & glue market globally. During a global recession, the bone cement & glue market could experience several potential impacts. Such as During a recession, healthcare budgets may be reduced as governments and individuals prioritize essential needs. This can lead to a decrease in demand for bone cement & glue as healthcare providers face financial constraints, Economic downturns often result in increased price sensitivity among healthcare providers and consumers. Manufacturers and suppliers of bone cement & glue may face pricing pressure as healthcare organizations seek more cost-effective alternatives or negotiate lower prices, in a recession, individuals may delay elective medical procedures due to financial constraints. This can impact the demand for bone cement & glue, particularly in orthopedic surgergical procedures.

Bone Cement & Glue Market Dynamics

DRIVER: Growing incidences of sports injuries

Globally, the incidence of sports injuries has increased over the last few years primarily due to the growing participation in sports as well as active participation in fitness activities (because of the growing focus on leading healthy lifestyles), Intensity and competitiveness, Insufficient recovery, and rest. Some of the major statistics in this regard have been mentioned below:

According to The Johns Hopkins University 2023, In the U.S., about 30 million children and teens participate in some form of organized sports, and more than 3.5 million injuries each year. Sports and recreational activities contribute to approximately 21% of all traumatic brain injuries among American children. Similarly, almost 50% of head injuries sustained in sports or recreational activities occur during bicycling, skateboarding, or skating incidents. More than 775,000 children, ages 14 and younger, are treated in hospital emergency rooms for sports-related injuries each year.

• In 2021, the United States, the National Athletic Trainers' Association (NATA) reports that an estimated 2 million high school athletes suffer sports-related injuries and 30,000 hospitalizations each year.
• According to the Centers for Disease Control and Prevention (CDC), approximately 8.6 million sports-related injuries occur each year, with more than 2.6 million of those injuries requiring medical attention. The most reported injuries are sprains, strains, fractures, and contusions. In addition, traumatic brain injuries and concussions have become a major focus of research and prevention efforts.
• As per the New York CNN 2023, Pickleball is America’s fastest-growing sport and Pickleball injuries may cost Americans USD 377 million in health care costs this year which is driving up the cost burden.
• As per the Australian Institute of Health and Welfare 2023, Injuries related to physical activity cost USD 164 million in emergency departments and USD 600 million for admitted patients.
• As per The Athletic Media Company 2023, Big Five’ leagues in the 2021-22, European season, injury costs for clubs reached £513.23 million, (USD 547.86) a 29% rise compared to the previous campaign (2021).

Hip-, knee-, and shoulder-related injuries are the major sports injuries. These injuries often require the replacement of the affected joint with a synthetic (metal) implant (arthroplasty), supplemented with bone cement and bone graft substitutes. With the increasing participation in sports and subsequent growth in the incidence of sports injuries, the demand for bone cement and glue is expected to increase across the globe during the forecast period.

Restraints: High costs and extensive clinical data requirements for launching new bone cements

The development of bone cement is an extremely cost-intensive process. It takes significant investments in R&D to develop new products that effectively cater to market needs. The FDA approval process for surgical orthopedic cements is stringent and time-consuming, causing delays in bringing new bone cements to the market. The FDA demands more clinical data related to the safety and efficacy of the product, which results in tin additional R&D investments for companies. Despite the development of several advanced cements in the market, there is still a need for developing cost-effective bone cements with the appropriate clinical data required by regulatory authorities.

Owing to the abovementioned factors, many small firms and start-ups do not focus on launching new innovative products in the market. Such companies are pressured to reevaluate the timelines and budgets required in product development, which ultimately affects their market survival. Moreover, due to the presence of alternatives such as bone staples and orthopedic pins, the uptake of advanced bone cements is affected. This, in turn, is restraining the growth of the overall market.

Some of the prices of commercially available bone cements are as below:

DePuy SmartSet Bone Cement - SmartSet HV Bone Cement, 40G, High-Viscosity - USD 400-500, Spineplex - Bone Cement 20 g Twin Pack (One-Half Dose) – USD 700-800, Palacos Bone Mixing Cements by Heraeus Medica - USD 800-900

OPPORTUNITY: Rising awareness and demand for minimally invasive procedures

Minimally invasive surgeries offer benefits such as smaller incisions, reduced scarring, and faster recovery times. There is an increasing demand for minimally invasive orthopedic procedures, and bone cement and glue play a crucial role in these techniques. Opportunities exist for the development of specialized bone cement and glue products tailored for minimally invasive approaches. Minimally invasive procedures often result in reduced post-operative pain, shorter hospital stays, and faster rehabilitation compared to traditional open surgeries. This can lead to improved patient satisfaction and outcomes. The use of appropriate bone cement and glue products in these procedures contributes to the overall success and effectiveness of the treatment.

• As per the PubMed 2022, Ambulatory Minimally invasive surgeries MIS procedures showed an increasing trend across years, representing 16.9%, 17.4%, and 18%, respectively. Healthcare Cost and Utilization Project (HCUPNet) data revealed an increase in inpatient MIS cases from 529,811 (8.9%) in 1993 to 1,443,446 (20.7%) in 2014.
• As per the Intuitive Surgical Operations, Inc. 2023 (US), through more than 10 million surgeries, Intuitive has become a leader in surgical robotics, increasing the adoption of minimally invasive surgery.

Minimally invasive procedures can be cost-effective compared to traditional open surgeries. They may result in lower healthcare resource utilization, reduced hospitalization costs, and quicker return to daily activities and work. Bone cement and glue products that support minimally invasive approaches align with the cost-saving goals of healthcare systems and providers. For instance, As per the article published in musculoskeletal key 2020, health care costs were nearly 18% of the U.S. gross domestic product (GDP), with the cost of surgical care was approximately 7% of GDP. The patients with Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF), the mean length of postoperative hospital stay was 3 days. The mean total in-hospitalization cost for these patients was USD 23,000. Each 1-day reduction in the length of stay results in a direct cost savings of USD 1,500. On the other hand, patients with open-TLIF, the mean length of postoperative hospital stay was 4 days. The mean total in-hospitalization cost for these patients was USD 25,000.Hence, the rising awareness and demand for minimally invasive procedures have a positive impact on the bone cement and glue market.

CHALLENGE: Product-related complications.

While bone cement and glue products are generally safe and effective, like any medical intervention, they can be associated with certain complications. Here are some potential complications associated with bone cement and glue:

• Infection: Infection is a possible complication following the use of bone cement and glue. Although efforts are made to maintain a sterile surgical environment, there is still a risk of bacterial contamination during the procedure or post-operatively. Infection can lead to implant loosening, prolonged healing, and the need for additional treatments or surgeries.
• Allergic reactions: Some individuals may experience allergic reactions to components of bone cement or glue, such as methacrylate monomers. Allergic reactions can manifest as localized inflammation, skin rashes, or more severe systemic reactions. Careful evaluation of patient history and selection of appropriate materials can help mitigate the risk of allergic reactions.
• Cement leakage: During the application of bone cement, there is a possibility of cement leakage into surrounding tissues or blood vessels. Cement leakage can lead to complications such as nerve impingement, embolism (if cement enters the bloodstream), or tissue damage. Proper surgical technique and monitoring can help reduce the risk of cement leakage.
• Implant loosening: Although bone cement is used to secure implants, there is still a possibility of implant loosening over time. Factors contributing to implant loosening include improper technique, poor bone quality, excessive weight-bearing, or inadequate cement fixation. Implant loosening may require revision surgery to address the instability and ensure long-term implant function.
• Adverse tissue reactions: Some individuals may experience adverse tissue reactions to bone cement or glue. These reactions can manifest as chronic inflammation, granuloma formation, or hypersensitivity reactions. The incidence of such reactions is relatively rare, but they can result in discomfort, implant failure, or the need for further interventions.
• Thermal necrosis: During the polymerization process of bone cement, heat is generated, which can potentially cause thermal necrosis (tissue damage due to excessive heat) in surrounding tissues. This risk is mitigated by proper cement handling, cooling techniques, and careful monitoring during the procedure.

Likewise, some of the Potential disadvantages of antibiotic-loaded bone cement are as below,

• Alteration in the mechanical and structural properties of the bone cement
• Antibiotic resistance
• Allergic reactions
• Systemic toxicity
• Cost implications

Based on Type, the Bone Glue market is segmented into Natural bone glue and Synthetic bone glue. The Natural bone glue segment is anticipated to have the highest shares during. The major factors contributing to the growth of this market are the potential advantages of natural bone glue include better biocompatibility, reduced risk of adverse reactions, and the ability to support tissue regeneration and healing. However, the development and commercialization of natural bone glue products have faced challenges such as standardization, and regulatory approvals.

Based on Loading, the Bone Cement & Glue market is segmented into Antibiotic-loaded bone cement, and non-Antibiotic-loaded bone cement. The Antibiotic-loaded bone cement segment is is anticipated to have the highest shares considering the applicatiobs as Antibiotic-loaded bone cement is also commonly used in revision surgeries, where there is a higher risk of infection due to the presence of existing implants, in addition, the effectiveness of antibiotic-loaded bone cement in reducing infection rates has been supported by clinical evidence and guidelines, making it a widely accepted and evidence-based practice. Likewise, Antibiotic-loaded bone cement maintains biocompatibility and bonding strength comparable to plain bone cement, making it a safe and effective option for surgical use.

Market Segments of Bone Cement & Glue Market.

US accounted for the largest share of the North American Bone cement & glue industry in 2022.

Based on the region, the North American bone cement & glue market is segmented into US and Canada. In 2022, the US accounted for the largest share of the North American Bone cement & glue market. Growth in this market can be attributed to presence of stringent regulatory standard, rising healthcare expenditure, the increasing number of orthopedic surgical procedures performed in the US, the rising geriatric population, and the strong presence of bone cement & glue manufacturers.

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India registered the highest growth rate in Asia Pacific Bone cement & glue industry.

The APAC bone cement & glue market is segmented into Japan, China, India, and Rest of Apac. In 2022, India accounted for the highest growth rate of the Asian bone cement & glue market. The high growth rate of India can be attributed to the rising of a medical tourism in orthopedic surgery sector and the increasing geriatric population. An increase in the number of elderly people gives rise to various orthopedic and diseases which is highly susceptible to several procedures. Therefore, growth in this population segment will directly drive the demand for bone cement & glue products.

The Germany in European Bone cement & glue industry to witness the second highest growth rate during the forecast period.

The Europe bone cement & glue market is segmented into Germany, France, the UK, and the Rest of Europe. Germany is registered the highest growth rate during the forecast period. The major factors contributing to the growth of this market are the high prevalence ofold age population, rising in sport related injuries, orthopedic cases, increasing R&D activities, strategic developments by key players.

Some of the major players operating in this market are Stryker (US), Zimmer Biomet (US) , Smith+Nephew.(UK), DePuy Synthes (a subsidiary of Johnson & Johnson - US) , Enovis  (US) , Artivion, Inc (US), Cardinal Health. (US), Medtronic (Ireland), Globus Medical (US), and Heraeus Holding (Germany).

In 2022, Stryker (US), held the leading position in the market. The company’s large share can be attributed to its broad range of Bone cement and strong global presence. Zimmer Biomet (US), held the second position in the Bone cement & glue market in 2022.

Scope of the Bone Cement & Glue Industry

This research report categorizes the Bone cement & glue market into the following segments and subsegments:

Recent Developments of Bone Cement & Glue Industry

• In 2021, The company Smith & Nephew (UK) acquired the Extremity Orthopedics business of Integra LifeSciences to expand its shoulder, upper, and lower extremities product portfolio.
• In 2021, Zimmer Biomet (US) Completed the spinoff of spine and dental businesses into a new public company, ZimVie Inc. (“ZimVie”). The transaction was intended to benefit its stockholders by enhancing the focus of both Zimmer Biomet and ZimVie to meet the needs of patients and customers

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