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Pulmonary Arterial Hypertension Market

Pulmonary Arterial Hypertension Market by Drug Class (SGC Stimulators, Endothelin Receptor Antagonists, Type (Innovative, Generics) – Global Forecast to 2027

Report Code: UC 6062 Jun, 2025, by marketsandmarkets.com

The global pulmonary arterial hypertension market is projected to reach USD 9 billion by 2027 from USD 7 billion in 2022, at a CAGR of 5% during the forecast period

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Pulmonary hypertension is high blood pressure in the pulmonary arteries, which carry oxygen-poor blood from heart to lungs. The major symptoms are shortness of breath, chest pain or pressure, dizziness or fainting, fatigue, and others. According to The American Journal of Managed Care, PAH is a rare disorder found in 15 to 50 persons per million within the United States and Europe. Idiopathic, heritable, and anorexigen-induced PAH make up 52.6% of all PAH cases. Usually, PAH affects women aged between 30 and 60 years. The rising prevalence of the PAH across the globe is increasing the demand for treatment options, these factors are likely to have higher impact on the market growth in coming years.

In the report, the pulmonary arterial hypertension market is segmented into drug class, type, route of administration, distribution channel and region. Based on the drug class the market is segmented into endothelin receptor antagonists, SGC Stimulators, PDE-5 Inhibitors, prostacyclin and prostacyclin analogs and others. Increase in number of FDA approvals in the prostacyclin and prostacyclin analogs drug class is likely to have higher impact on the adoption and sales across the globe. For instance, In July 2021, Uptravi belonging to Prostacyclin and Prostacyclin Analogs segment received FDA approval for intravenous use in pulmonary arterial hypertension patients. Various SGC stimulators products under phase 2 and phase 3 clinical trials are likely to get approvals during the forecast period. For instance, Merck Sharp & Dohme LLC, candidate MK-5475 is under phase 2 clinical trial and expected to be launch in coming 3-4 years. The study is for MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH).

Based on region the market is further divided into North America, Europe, Asia Pacific, and ROW (Rest of the World). Among the region North America is expected hold dominant share throughout the forecast period. The dominance is attributed to rising incidence & prevalence of pulmonary arterial hypertension in the region. Furthermore, rising investment in development & launch of new drugs in the market is likely to increase consumption hence contributing towards revenue growth in the region.

The major players operating in the pulmonary arterial hypertension market are United Therapeutics Corporation (US), BAYER (Germany), Gilead Sciences, Inc. (US), Johnson & Johnson (US), Viatris Inc. (US), Teva Pharmaceutical Industries Ltd. (Israel) and among others.

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Scope of the Report

Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by high blood pressure (hypertension) in the arteries of the lungs (pulmonary artery) for no apparent reason. PAH occurs 3-5 times more often in females than in males. It tends to affect females between the ages of 30 and 60. Around 500-1000 new cases of PAH are diagnosed each year in the U.S. Rising prevalence is increasing demand for the treatment options hence projecting the market growth.

Global Pulmonary Arterial Hypertension Market

The research report categorizes the Pulmonary Arterial Hypertension Market into following segments.

Pulmonary Arterial Hypertension Market, By Drug Class
  • Endothelin Receptor Antagonists
  • SGC Stimulators
  • PDE-5 Inhibitors
  • Prostacyclin &Prostacyclin Analogs
  • Others
Pulmonary Arterial Hypertension Market, By Route of Administration
  • Oral
  • Intravenous/ Subcutaneous
  • Others
Pulmonary Arterial Hypertension Market, By Type
  • Innovative
  • Generics
Pulmonary Arterial Hypertension Market, By Distribution Channel
  • Hospitals
  • Retail Pharmacies
  • Online Pharmacies
Pulmonary Arterial Hypertension Market, By Region
  • North America
    • US
    • Canada
  • Europe
    • Germany
    • France
    • UK
    • ROE
  • Asia Pacific
    • Japan
    • China
    • India
    • Rest Of APAC
  • Rest Of the World (Row)
    • Latin America
    • Middle East & Africa

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TABLE OF CONTENTS

1 INTRODUCTION 
    1.1 OBJECTIVES OF THE STUDY
    1.2 MARKET DEFINITION
           1.2.1 INCLUSIONS & EXCLUSIONS
    1.3 MARKET SCOPE
           1.3.1 MARKET COVERED
           1.3.2 YEARS CONSIDERED FOR THE STUDY
    1.4 CURRENCY
    1.5 LIMITATIONS
    1.6 STAKEHOLDERS

2 RESEARCH METHODOLOGY 
    2.1 RESEARCH DATA
           2.1.1 SECONDARY DATA
           2.1.2 PRIMARY DATA
                    2.1.2.1 Key industry insights
    2.2 MARKET SIZE ESTIMATION
    2.3 MARKET GROWTH RATE PROJECTIONS
    2.4 MARKET BREAKDOWN AND DATA TRIANGULATION
    2.5 ASSUMPTIONS FOR THE STUDY

3 EXECUTIVE SUMMARY 

4 PREMIUM INSIGHTS 

5 MARKET OVERVIEW 
    5.1 INTRODUCTION
    5.2 MARKET DYNAMICS
           5.2.1 DRIVERS
           5.2.2 RESTRAINTS
           5.2.3 OPPORTUNITIES
           5.2.4 CHALLENGES
    5.3 TRENDS/DISRUPTIONS IMPACTING CUSTOMER’S BUSINESS
    5.4 PRICING ANALYSIS
    5.5 VALUE CHAIN ANALYSIS
    5.6 ECOSYSTEM ANALYSIS
    5.7 PATENT ANALYSIS
    5.8 KEY CONFERENCES AND EVENTS IN 2022-2023
    5.9 REGULATORY ANALYSIS
    5.10 PORTER’S FIVE FORCES ANALYSIS
    5.11 KEY STAKEHOLDER AND BUYING CRITERIA

6 PULMONARY ARTERIAL HYPERTENSION MARKET, BY DRUG CLASS, 2020-2027 (USD MILLION) 
    6.1 INTRODUCTION 
    6.2 ENDOTHELIN RECEPTOR ANTAGONISTS
    6.3 SGC STIMULATORS 
    6.4 PDE-5 INHIBITORS
    6.5 PROSTACYCLIN AND PROSTACYCLIN ANALOGS
    6.6 OTHERS 

7 PULMONARY ARTERIAL HYPERTENSION MARKET, BY ROUTE OF ADMINISTRATION, 2020-2027 (USD MILLION) 
    7.1 INTRODUCTION
    7.2 ORAL
    7.3 INTRAVENOUS/ SUBCUTANEOUS
    7.4 OTHERS

8 PULMONARY ARTERIAL HYPERTENSION MARKET, BY TYPE, 2020-2027 (USD MILLION) 
    8.1 INTRODUCTION
    8.2 INNOVATIVE
    8.3 GENERICS

9 PULMONARY ARTERIAL HYPERTENSION MARKET, BY DISTRIBUTION CHANNEL, 2020-2027 (USD MILLION) 
    9.1 INTRODUCTION
    9.2 HOSPITALS
    9.3 RETAIL PHARMACIES
    9.4 ONLINE PHARMACIES

10 PULMONARY ARTERIAL HYPERTENSION MARKET, BY REGION, 2020-2027 (USD MILLION) 
     10.1 INTRODUCTION
     10.2 NORTH AMERICA
             10.2.1 US
             10.2.2 CANADA
     10.3 EUROPE
             10.3.1 GERMANY
             10.3.2 FRANCE
             10.3.3 UK
             10.3.4 ROE
     10.4 ASIA PACIFIC
             10.4.1 JAPAN
             10.4.2 CHINA
             10.4.3 INDIA
             10.4.4 REST OF APAC
     10.5 REST OF THE WORLD (ROW)
             10.5.1 LATIN AMERICA
             10.5.2 MIDDLE EAST & AFRICA

11 COMPETITIVE LANDSCAPE 
     11.1 OVERVIEW
     11.2 KEY PLAYER STRATEGIES
     11.3 REVENUE SHARE ANALYSIS OF TOP MARKET PLAYERS
     11.4 MARKET SHARE ANALYSIS, 2021
     11.5 COMPANY EVALUATION QUADRANT
     11.6 COMPANY EVALUATION QUADRANT – SME/START-UPS
     11.7 COMPANY GEOGRAPHIC FOOTPRINT
     11.8 COMPETITIVE SCENARIO

12 COMPANY PROFILES 
(The details on business overview, financial information, products/services portfolio, recent developments, MarketsandMarkets view will be provided)*
     12.1 UNITED THERAPEUTICS CORPORATION
     12.2 BAYER
     12.3 GILEAD SCIENCES, INC.
     12.4 JOHNSON & JOHNSON
     12.5 VIATRIS INC
     12.6 TEVA PHARMACEUTICAL INDUSTRIES LTD.
     12.7 ACTELION PHARMACEUTICALS LTD. 
     12.8 LUPIN
     12.9 SUN PHARMACEUTICAL INDUSTRIES LTD.
     12.10 GSK PLC
     12.11 ELI LILLY AND COMPANY
     12.12 PFIZER INC

* Details on business overview, financial information, products/services portfolio, recent developments, MarketsandMarkets view might not be captured in case of unlisted companies.

12 APPENDIX 
     12.1 INSIGHTS FROM INDUSTRY EXPERTS
     12.2 DISCUSSION GUIDE
     12.3 KNOWLEDGE STORE: MARKETSANDMARKETS’ SUBSCRIPTION PORTAL
     12.4 INTRODUCING RT: REAL-TIME MARKET INTELLIGENCE
     12.5 AVAILABLE CUSTOMIZATIONS
     12.6 RELATED REPORTS
     12.7 AUTHOR DETAILS


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