Microbiome Sequencing Services Market: Growth, Size, Share, and Trends

Market Growth Outlook Summary

The global microbiome sequencing services market growth forecasted to transform from USD 284 million in 2023 to USD 555 million by 2028, driven by a CAGR of 14.3%. Factors contributing to market growth include the high demand for metagenomic sequencing, the increasing use of sequencing technologies in developing human microbiome therapeutics, and the expenses associated with advanced sequencing equipment, which drive end users to outsource microbiome sequencing. However, the lack of skilled expertise in handling complex samples may hinder the market's growth during the forecast period.

Microbiome Sequencing Services Market – Global Forecast and Growth Insights to 2028

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Microbiome Sequencing Services Market – Global Forecast and Key Opportunities to 2028

Microbiome Sequencing Services Market Dynamics to 2028

DRIVER: High cost of advanced infrastructure for sequencing

The field of microbiome sequencing requires sophisticated and expensive equipment, such as next-generation sequencing (NGS) platforms, bioinformatics tools, and data storage and analysis capabilities. Setting up and maintaining such infrastructure can be cost-prohibitive for many research and academic institutes, pharmaceutical and biotechnology companies, and other end users. Outsourcing microbiome sequencing to specialized service providers allows professionals to access advanced infrastructure and expertise without the need for substantial upfront investments. These service providers typically have state-of-the-art facilities and experienced personnel who are skilled in performing microbiome sequencing using the latest technologies and methodologies. Through outsourcing, professionals can leverage the capabilities of these specialized facilities without the burden of capital expenditures, operational costs, and maintenance expenses associated with in-house infrastructure.

RESTRAINT: Dearth of skilled personnel

The shortage of skilled personnel with expertise in sequencing and data analysis is a significant challenge in the field of microbiome sequencing. Microbiome research involves complex methodologies, including sample collection, DNA extraction, library preparation, sequencing, and data analysis. The proper execution of these steps requires specialized knowledge and technical expertise. However, the field of microbiome sequencing is relatively new and evolving rapidly, with a shortage of skilled personnel with the necessary expertise. Training and developing skilled personnel in microbiome sequencing can be time-consuming and resource-intensive, and there may be a lag in keeping up with the latest advancements in sequencing technologies and data analysis methods.

OPPORTUNITY: Expanding applications of microbiome sequencing in therapeutics development

Oral microbiome sequencing can provide insights into the microbial etiology of oral health conditions, identify key pathogenic species or functional genes associated with oral diseases, and reveal potential therapeutic targets for intervention. This knowledge can be used to develop novel strategies for oral health management, including probiotics, antimicrobial treatments, and personalized oral care regimens tailored to an individual's oral microbiome.

CHALLENGE: Issues related to sample preparation/isolation of microbes for sequencing

Despite the success of using metagenomic sequence data to guide the isolation and cultivation of microbes, there are still challenges and limitations that need to be addressed for more widespread success. Anaerobic microbes may also pose technical challenges for some targeted isolation methods due to limitations with cell sorters. Determining suitable growth media and physicochemical conditions for target organisms based solely on genome sequences can be challenging, as natural environment compositions are often unknown. Contamination can also be a significant challenge in microbiome research, as it can introduce non-target microbial DNA from external sources during sample collection, processing, and sequencing. Contamination can arise from reagents, equipment, and environmental sources, leading to false-positive or false-negative results. Proper controls, including negative controls and rigorous contamination prevention measures, should be implemented to minimize contamination and ensure accurate and reliable sequencing results.

Microbiome Sequencing Services Market Map & Ecosystem Overview

Microbiome sequencing services start with outsourcing of study design, wherein the service provider helps in the implementation and validation of the hypothesis and the variables of interest in a sequencing project. Different variables in the aspect of study design include the number of samples required, apt sequencing technology to be used, and the requirement of follow-up studies. Service providers have expertise with respect to the collection, storage, and transport options optimized for this workflow. NGS instruments are predominantly used for the sequencing of DNA and RNA samples. Shotgun metagenomics sequencing is offered by a majority of sequencing service providers, even for deep-sequenced samples. DNA library preparation is verified for quality and yield. Genomic DNA is fragmented at specific sizes suitable for the purification/separation of desired proteins and nucleic acids.

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Based on service, sequencing and library preparation services segment accounted for the largest share of the Microbiome Sequencing Services Market in 2022

Based on service, the market is segmented into sample preparation services, sequencing and library preparation services, and data analysis services. The sequencing and library preparation services segment accounted for the largest share of the market whereas sample preparation services segment accounted for the second-largest share in 2022. Sample preparation segment includes services that are applied for the collection, storage, and processing of samples subjected to microbiome sequencing. It is imperative to ensure that microbiome analysis is reproducible. Reproducibility is affected by several factors, such as sample size, storage methods, and collection methods.

Based on type, amplicon sequencing segment accounted for the largest share of the Microbiome Sequencing Services Market in 2022

Based on type, the global market is segmented into amplicon sequencing, whole-genome sequencing, shotgun sequencing, and other types. Other types of sequencing include metagenomic sequencing, de novo sequencing, and metatranscriptomic sequencing. High accuracy of 16S amplicon sequencing is the key contributor to the dominance of amplicon sequencing segment. Additionally, the demand for targeted sequencing is anticipated to increase in metagenomic research activities. The targeted amplicon sequencing method involves sequencing a phylogenetically informative marker to identify organisms in community samples.

Based on technology, nanopore sequencing segment of the global Microbiome Sequencing Services Market is expected to grow with a highest CAGR throughout the forecast period

Based on technology, the global market is segmented into sequencing by synthesis (SBS), sequencing by ligation (SBL), nanopore sequencing, and other technologies. Introduced by Oxford Nanopore Technologies, nanopore sequencing technology (which is considered the fourth generation of sequencing) has emerged as a competitive, portable technology. The technology works through the detection of unique electrical signals of different molecules as they pass across the nanopore with a semiconductor-based electronic detection system. This technology makes for a high throughput, cost-effective sequencing solution.

The North American market is projected to contribute the largest share for the microbiome sequencing services market.

The global market is segmented into five major regions—North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa. North America is the largest regional market for microbiome sequencing services. US has emerged as the key revenue contributor to this region. The US market is a rapidly growing and dynamic market that is driven by several factors. One of the key drivers for market growth in the US is the increasing awareness and understanding of the role of the microbiome in human health. Research has shown that microorganisms residing in and on the human body play a crucial role in various physiological processes, including digestion, immunity, and metabolism. The increasing focus on gaining a deep understanding of this has driven the demand for microbiome sequencing services to study the composition and function of the microbiome.

Microbiome Sequencing Services Market by Region – Forecast to 2028

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The global microbiome sequencing services market is highly fragmented, with Charles River Laboratories (US), Eurofins Scientific (France), and BGI (China) emerging as the top three players in the global market. Other prominent players include CosmosID (US), Microba (Australia), QIAGEN (Germany), Microbiome Insights (Canada), BaseClear (Netherlands), CD Genomics (US), Zymo Research (US), OraSure Technologies (US), MR DNA (US), Eremid Genomic Services (US), Clinical-Microbiomics A/S (Denmark), Novogene Co., Ltd. (China), EzBiome (US), Boster Biological Technology (US), Zifo (India), omics2view.consulting GbR (Germany), and Macrogen, Inc. (South Korea).

Microbiome Sequencing Services Market Report Scope and Insights

Microbiome Sequencing Services Market Segmentation and Analysis

By Service

• Sample Preparation
• Sequencing and Library Preparation
• Data Analysis

By Type

• Amplicon Sequencing
• Whole-genome Sequencing
• Shotgun Sequencing
• Other Types

By Technology

• Sequencing by Synthesis (SBS)
• Sequencing by Ligation (SBL)
• Nanopore Sequencing
• Other Technologies

By End User

• Pharmaceutical and Biotechnology Companies
• Academic and Research Institutes
• Other End Users

By Region

• North America
  • US
  • Canada
• Europe
  • Germany
  • UK
  • France
  • Spain
  • Italy
  • RoE
• Asia Pacific
  • China
  • India
  • Japan
  • RoAPAC
• Latin America
• Middle East & Africa

Microbiome Sequencing Services Market Recent Developments and Insights

• In March 2023, Microba launched a new human gut microbiome testing service for comprehensive gastrointestinal testing solutions. The solutions are accessible to healthcare professionals in Australia through a different brand name, Co-Biome.
• In February 2023, Locus Biosciences announced a long-term partnership with CosmosID to gain the support of the latter for clinical trial studies. CosmosID’s support for microbiome analysis is expected to assist Locus Biosciences in strengthening its precision therapeutics platform.
• In March 2022, Diversigen announced the launch of a new service, metatranscriptomic sequencing and analysis of the gut microbiome. This service will assist research professionals in understanding gene expression while gaining insights into both function and mechanism of microbiomes in samples.

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