Knock out Mouse Model Market

Mice models are indispensable tools in research activities with their capability to elucidate human disease processes, due to striking similarities between the anatomy, physiology, and genetics of humans and mice. These advantages promote scientific discovery, understanding of the functions of individual genes, mechanisms of different diseases, and the effectiveness and toxicities of various drug molecules. Mice models are the most popularly used animal models due to their small size, short generation time, accelerated lifespan, low cost, and requirement of less space. These factors help in accelerating the research and development of drug therapies.

Knockout mice are produced by inactivating/silencing or "knocking out" an existing gene and replacing it with an artificial piece of DNA, thereby resulting in the loss of gene activity. This leads to changes in the mouse's phenotypic characteristics, such as appearance, behavior, and other observable biochemical characteristics.

Different research areas that widely use knockout/ knock-in mice include studying and modeling different types of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging, and Parkinson’s disease, among others.

Apart from rampant use of knockout/ knock-in mice in diverse research areas, continuous introduction of new models coupled with signing of various licensing agreements that adds to the widened usage of the models is providing impetus for growth of this market.

Clinical Research Organizations (CROs), Mice Model and Services Distributors, Academic Institutes, Government and Private Research Institutes, and Medical Research Centers are some of the are some of the key stakeholders who are likely to benefit from the pricing assessment of knock-out mice. The report will enrich both established firms as well as new entrants/smaller firms to gauge the price variation of knock-out mice models. Pricing assessment of knock-out mice models would help stakeholders in the market to align or re-align their business strategies with respect to pricing of these models. Appropriate pricing of these models is likely to translate into greater revenue share and customer base for the stakeholders in the market.

Knock out Mice Model Market Report Scope

This report provides pricing assessment of the knock-out mice models in terms of indications, type, physiological characteristics, end users, economic model, business model, stakeholders, agreements, and discounts.

Introduction

• Scope of the study
• Factors affecting cost of knock-out mice

Indications

• Commonly available knockout mice cost less
• Cost of knockout mice models for other disorders relatively high
• Cancer knockout mice models priced lower
• Rare diseases driving demand for customized models
• Price tables for non-obese diabetic (nod) SCID mice, by company
  • The Jackson Laboratory
  • Harlan Laboratories (Now part of Envigo)
  • Charles River Laboratories, Inc.
  • Taconic Biosciences, Inc.
• Price variation of non-obese diabetic mice (NON SCID), by company

Types of Knockout Mice

• Price of knockout mice, by type (2-in-1, constitutive, conditional, cluster)
• Conditional knockouts highly complex and priced high
• Customized knockout can cost up to USD 100,000

Economic Model of Demand & Supply

• Mice models for autism, schizophrenia, Alzheimer’s gaining popularity

Agreements

• Agreements impact cost of knockout mice models
• Price determination illustration in a business segment
• Illustrative examples

Discounts

• Bulk, seasonal and other discounts impact pricing

Physiological Characteristics

• Price variation for obesity (c57bl6) mice models, by weight, sex and age

End Users

• Commercial customers charged higher than non-profits

Business Models

• Technology licensing
• Co-distribution through partnerships/agreements
• Independent commercial production

Stakeholders

• Key stakeholders for mass produce and customized mice models
• Indicative list of buying companies and universities

Available Customizations

Pricing analysis on the indicative parameters like indications, type of knock-outs, discounts, agreements, demand & supply, and physiological characteristics can be carried for other type of models like:

• Inbred mice
• Outbred mice
• Conditioned/ surgically modified mice
• Hybrid/ congenic
• Spontaneous mutant mice

Mice serve as appropriate study models for a variety of diseases because of their close genetic and physiological similarities to humans as well as the ease with which their genomes can be manipulated and analyzed. Knockout mice models are of paramount importance in biomedical researches which focus on finding cure for human diseases.

Market players are continuously focusing on innovations in mice models for research on various human diseases. Growing innovations and advances in mice models are providing increased options to researchers to conduct research activities in particular diseases, which is a major factor driving market growth.

Oncology knockout mice are in high demand, owing to the increasing number of cancer research activities and increasing innovation in mice models that are tailored to meet cancer research needs. Thus, the popularity and availability of cancer knockout mice has led to reduction in the cost of these models. In the present scenario, the availability of knockout mice models for rare diseases is low and the cost of these models is relatively higher as compared to knockout mice models for common indications such as cancer, cardiovascular diseases, and diabetes.

In addition, the type of the knock-out mice developed determines the complexity of the project and thus, the price of the knock-out mice model. Development of Cluster Knockout is highly complex as it involves knocking out of many genes at once. Thus the price of cluster knockout is higher than other types of knockout.

The demand & supply status of the knock-out mice also affect the pricing trend. For instance, Knockout mice models for cancer, cardiovascular diseases, neurological disorders, and diabetes are well-established, available in sufficient supply, and priced lower than the knockout mice models that address indications such as neurological disorders and rare diseases. Knockout models for rare diseases are in low supply as research in these fields is yet to gain momentum. With a steady increase in research activities and low supply of knockout models for these indications, the demand for customized knockout mice for these indications is likely to grow, thus leading to their high price.

The price also depends upon the type of agreements within the research organizations. The price is high in case the agreements are for commercial purposes and low if the agreements are for a non-commercial and non-profit purpose.

Similarly, some other factors like physiological characteristics, discounts, end users, among others affect the pricing range of the knock-out mice models.

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