Microbiome Sequencing Services Market by Service (Sample Preparation, Sequencing, Library Preparation), Type (Amplicon Sequencing, Whole Genome Sequencing), Technology (Sequencing by Synthesis, Nanopore Sequencing), End User - Global Forecast to 2028
The global microbiome sequencing services market in terms of revenue was estimated to be worth $284 million in 2023 and is poised to reach $555 million by 2028, growing at a CAGR of 14.3% from 2023 to 2028. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. Rising focus on human microbiome therapeutics development has emerged as one of the key driving factors for market growth. The increasing focus on human microbiome therapeutics development is driving therapeutics manufacturers to opt for sequencing, sample preparation, and data analysis services. This is further propelled by the need for a deeper understanding of the microbiome, including its composition, function, and interaction with the host to develop microbiome-based therapeutics. Microbiome sequencing plays a critical role in providing this understanding by allowing for the identification and characterization of the microorganisms that make up the microbiome.
Attractive Opportunities in the Microbiome Sequencing Services Market
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Microbiome Sequencing Services Market Dynamics
DRIVER: High cost of advanced infrastructure for sequencing
The field of microbiome sequencing requires sophisticated and expensive equipment, such as next-generation sequencing (NGS) platforms, bioinformatics tools, and data storage and analysis capabilities. Setting up and maintaining such infrastructure can be cost-prohibitive for many research and academic institutes, pharmaceutical and biotechnology companies, and other end users. Outsourcing microbiome sequencing to specialized service providers allows professionals to access advanced infrastructure and expertise without the need for substantial upfront investments. These service providers typically have state-of-the-art facilities and experienced personnel who are skilled in performing microbiome sequencing using the latest technologies and methodologies. Through outsourcing, professionals can leverage the capabilities of these specialized facilities without the burden of capital expenditures, operational costs, and maintenance expenses associated with in-house infrastructure.
RESTRAINT: Dearth of skilled personnel
The shortage of skilled personnel with expertise in sequencing and data analysis is a significant challenge in the field of microbiome sequencing. Microbiome research involves complex methodologies, including sample collection, DNA extraction, library preparation, sequencing, and data analysis. The proper execution of these steps requires specialized knowledge and technical expertise. However, the field of microbiome sequencing is relatively new and evolving rapidly, with a shortage of skilled personnel with the necessary expertise. Training and developing skilled personnel in microbiome sequencing can be time-consuming and resource-intensive, and there may be a lag in keeping up with the latest advancements in sequencing technologies and data analysis methods.
OPPORTUNITY: Expanding applications of microbiome sequencing in therapeutics development
Oral microbiome sequencing can provide insights into the microbial etiology of oral health conditions, identify key pathogenic species or functional genes associated with oral diseases, and reveal potential therapeutic targets for intervention. This knowledge can be used to develop novel strategies for oral health management, including probiotics, antimicrobial treatments, and personalized oral care regimens tailored to an individual's oral microbiome.
CHALLENGE: Issues related to sample preparation/isolation of microbes for sequencing
Despite the success of using metagenomic sequence data to guide the isolation and cultivation of microbes, there are still challenges and limitations that need to be addressed for more widespread success. Anaerobic microbes may also pose technical challenges for some targeted isolation methods due to limitations with cell sorters. Determining suitable growth media and physicochemical conditions for target organisms based solely on genome sequences can be challenging, as natural environment compositions are often unknown. Contamination can also be a significant challenge in microbiome research, as it can introduce non-target microbial DNA from external sources during sample collection, processing, and sequencing. Contamination can arise from reagents, equipment, and environmental sources, leading to false-positive or false-negative results. Proper controls, including negative controls and rigorous contamination prevention measures, should be implemented to minimize contamination and ensure accurate and reliable sequencing results.
Microbiome Sequencing Services: Market Ecosystem
Microbiome sequencing services start with outsourcing of study design, wherein the service provider helps in the implementation and validation of the hypothesis and the variables of interest in a sequencing project. Different variables in the aspect of study design include the number of samples required, apt sequencing technology to be used, and the requirement of follow-up studies. Service providers have expertise with respect to the collection, storage, and transport options optimized for this workflow. NGS instruments are predominantly used for the sequencing of DNA and RNA samples. Shotgun metagenomics sequencing is offered by a majority of sequencing service providers, even for deep-sequenced samples. DNA library preparation is verified for quality and yield. Genomic DNA is fragmented at specific sizes suitable for the purification/separation of desired proteins and nucleic acids.
Prominent players in this market include Charles River Laboratories (US), Eurofins Scientific (France), BGI (China), CosmosID (US), Microba (Australia), QIAGEN (Germany), Microbiome Insights (Canada), BaseClear (Netherlands), CD Genomics (US), Zymo Research (US), OraSure Technologies (US), MR DNA (US), Eremid Genomic Services (US), Clinical-Microbiomics A/S (Denmark), Novogene Co., Ltd. (China), EzBiome (US), Boster Biological Technology (US), Zifo (India), omics2view.consulting GbR (Germany), and Macrogen, Inc. (South Korea).
Ecosystem Analysis: Microbiome Sequencing Services Market
Source: Annual Reports, SEC Filings, Investor Presentations, Expert Interviews, and MarketsandMarkets Analysis
Based on service, sequencing and library preparation services segment accounted for the largest share of the Microbiome Sequencing Services Market in 2022
Based on service, the market is segmented into sample preparation services, sequencing and library preparation services, and data analysis services. The sequencing and library preparation services segment accounted for the largest share of the market whereas sample preparation services segment accounted for the second-largest share in 2022. Sample preparation segment includes services that are applied for the collection, storage, and processing of samples subjected to microbiome sequencing. It is imperative to ensure that microbiome analysis is reproducible. Reproducibility is affected by several factors, such as sample size, storage methods, and collection methods.
Based on type, amplicon sequencing segment accounted for the largest share of the Microbiome Sequencing Services Market in 2022
Based on type, the global market is segmented into amplicon sequencing, whole-genome sequencing, shotgun sequencing, and other types. Other types of sequencing include metagenomic sequencing, de novo sequencing, and metatranscriptomic sequencing. High accuracy of 16S amplicon sequencing is the key contributor to the dominance of amplicon sequencing segment. Additionally, the demand for targeted sequencing is anticipated to increase in metagenomic research activities. The targeted amplicon sequencing method involves sequencing a phylogenetically informative marker to identify organisms in community samples.
Based on technology, nanopore sequencing segment of the global Microbiome Sequencing Services Market is expected to grow with a highest CAGR throughout the forecast period
Based on technology, the global market is segmented into sequencing by synthesis (SBS), sequencing by ligation (SBL), nanopore sequencing, and other technologies. Introduced by Oxford Nanopore Technologies, nanopore sequencing technology (which is considered the fourth generation of sequencing) has emerged as a competitive, portable technology. The technology works through the detection of unique electrical signals of different molecules as they pass across the nanopore with a semiconductor-based electronic detection system. This technology makes for a high throughput, cost-effective sequencing solution.
The North American market is projected to contribute the largest share for the microbiome sequencing services market.
The global market is segmented into five major regions—North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa. North America is the largest regional market for microbiome sequencing services. US has emerged as the key revenue contributor to this region. The US market is a rapidly growing and dynamic market that is driven by several factors. One of the key drivers for market growth in the US is the increasing awareness and understanding of the role of the microbiome in human health. Research has shown that microorganisms residing in and on the human body play a crucial role in various physiological processes, including digestion, immunity, and metabolism. The increasing focus on gaining a deep understanding of this has driven the demand for microbiome sequencing services to study the composition and function of the microbiome.
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The global microbiome sequencing services market is a fragmented market, with Charles River Laboratories (US), Eurofins Scientific (France), and BGI (China) emerging as the top 3 players of the global market. Players such as CosmosID (US), Microba (Australia), QIAGEN (Germany), Microbiome Insights (Canada), BaseClear (Netherlands), CD Genomics (US), Zymo Research (US), OraSure Technologies (US), MR DNA (US), Eremid Genomic Services (US), Clinical-Microbiomics A/S (Denmark), Novogene Co., Ltd. (China), EzBiome (US), Boster Biological Technology (US), Zifo (India), omics2view.consulting GbR (Germany), and Macrogen, Inc. (South Korea) are some of the prominent players in the market.
Microbiome Sequencing Services Market Report Scope
Report Metric |
Details |
Market Revenue in 2023 |
$284 million |
Projected Revenue by 2028 |
$555 million |
Revenue Rate |
Poised to Grow at a CAGR of 14.3% |
Market Driver |
High cost of advanced infrastructure for sequencing |
Market Opportunity |
Expanding applications of microbiome sequencing in therapeutics development |
This research report categorizes the microbiome sequencing services market to forecast revenue and analyze trends in each of the following submarkets:
By Service
- Sample Preparation
- Sequencing and Library Preparation
- Data Analysis
By Type
- Amplicon Sequencing
- Whole-genome Sequencing
- Shotgun Sequencing
- Other Types
By Technology
- Sequencing by Synthesis (SBS)
- Sequencing by Ligation (SBL)
- Nanopore Sequencing
- Other Technologies
By End User
- Pharmaceutical and Biotechnology Companies
- Academic and Research Institutes
- Other End Users
By Region
-
North America
- US
- Canada
-
Europe
- Germany
- UK
- France
- Spain
- Italy
- RoE
-
Asia Pacific
- China
- India
- Japan
- RoAPAC
- Latin America
- Middle East & Africa
Recent Developments
- In March 2023, Microba launched a new human gut microbiome testing service for comprehensive gastrointestinal testing solutions. The solutions are accessible to healthcare professionals in Australia through a different brand name, Co-Biome.
- In February 2023, Locus Biosciences announced a long-term partnership with CosmosID to gain the support of the latter for clinical trial studies. CosmosID’s support for microbiome analysis is expected to assist Locus Biosciences in strengthening its precision therapeutics platform.
- In March 2022, Diversigen announced the launch of a new service, metatranscriptomic sequencing and analysis of the gut microbiome. This service will assist research professionals in understanding gene expression while gaining insights into both function and mechanism of microbiomes in samples.
Frequently Asked Questions (FAQ):
What is the projected market revenue value of the microbiome sequencing services market?
The microbiome sequencing services market boasts a total revenue value of $555 million by 2028.
What is the estimated growth rate (CAGR) of the microbiome sequencing services market?
The global microbiome sequencing services market has an estimated compound annual growth rate (CAGR) of 14.3% and a revenue size in the region of $284 million in 2023.
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This study involved four major activities in estimating the current size of the microbiome sequencing services market. Exhaustive secondary research was carried out to collect information on the market, its peer markets, and its parent market. The next step was to validate these findings, assumptions, and sizing with industry experts across the value chain through primary research. Both top-down and bottom-up approaches were employed to estimate the complete market size. After that, market breakdown and data triangulation procedures were used to estimate the market size of segments.
Secondary Research
Secondary research was used mainly to identify and collect information for the extensive, technical, market-oriented, and commercial study of the microbiome sequencing services market. The secondary sources used for this study include publications from government sources National Human Genome Research Institute (NHGRI), the National Center for Biotechnology Information (NCBI), the Genomics Research and Development Initiative (GRDI), UK Research and Innovation (UKRI), Microbiome Foundation France, the Centre for Genomic Regulation (CRG) Spain, Human MetaGenome Consortium Japan (HMGJ), Microbiome Research Centre (MRC) Australia, Center of Innovation in Personalized Medicine (CIPM), Department of Biotechnology (GENOME India and Microbiome) India, South African Society for Human Genetics, Food and Drug Administration (FDA), Annual Reports, SEC Fillings, Press Releases, Investor Presentation, Expert Interviews, and MarketsandMarkets Analysis. These sources were also used to obtain key information about major players, market classification, and segmentation according to industry trends, regional/country-level markets, market developments, and technology perspectives.
Primary Research
In-depth interviews were conducted with various primary respondents, including key industry participants, subject-matter experts (SMEs), C-level executives of key market players, and industry consultants, among other experts, to obtain and verify the critical qualitative and quantitative information as well as assess prospects of the market. Various primary sources from both the supply and demand sides of the market were interviewed to obtain qualitative and quantitative information.
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Market Size Estimation
Both top-down and bottom-up approaches were used to estimate and validate the total size of the microbiome sequencing services market. These methods were also used extensively to estimate the size of various segments in the market. The research methodology used to estimate the market size includes the following:
- The key players in the industry and markets have been identified through extensive secondary research
- The industry’s supply chain and market size, in terms of value, have been determined through primary and secondary research processes
- All percentage shares, splits, and breakdowns have been determined using secondary sources and verified through primary sources
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Data Triangulation
After arriving at the overall market size—using the market size estimation processes—the market was split into several segments. To complete the overall market engineering process and arrive at the exact statistics of each market segments, the data triangulation, and market breakdown procedures were employed, wherever applicable. The data was triangulated by studying various factors and trends from both the demand and supply sides in the microbiome sequencing services industry.
Market Definition
Microbiome sequencing is applied to decode the genetic material of all the microorganisms in a given sample which may contain bacteria, viruses, or fungi. Whole-genome sequencing (WGS) and amplicon sequencing are the two key microbiome sequencing services. Sequencing-based detection of microorganisms exhibits different advantages over traditional approaches, some of which are mentioned below:
- Detection of anaerobic bacteria
- More cost-effective microbiome characterization of multiplex microbial samples
- Identification of non-cultivable bacteria
- Estimate the relative abundance of microbes in a sample
- Profile hundreds of microorganisms in a single analysis
- Examine complex microbiomes and microbiota communities
The microbiome sequencing services market comprises services employed for sample preparation, sequencing, library preparation, and data analysis suitable for different samples, including human microbiome samples and environmental samples.
Key Stakeholders
- Research Institutes
- Pharmaceutical and Biotechnology Companies
- Microbiome Sequencing Service Providers
- Metagenomic Sequencing Service Providers
- NGS Service Providers
- Venture Capitalists and Investors
- Contract Research Organizations
- Government Associations
- Healthcare Associations/Institutes
- Business Research and Consulting Service Providers
Report Objectives
- To define, describe, and forecast the global microbiome sequencing services market based on service, type, technology, end user, and region
- To provide detailed information regarding the major factors influencing the market growth (such as drivers, restraints, challenges, and opportunities)
- To strategically analyze micromarkets with respect to individual growth trends, prospects, and contributions to the overall market
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To analyze the opportunities in the market for stakeholders and provide details of
the competitive landscape for market leaders operating in the market - To forecast the revenue of the market with respect to five regional segments—North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa
- To profile the key market players and comprehensively analyze their service portfolios, market positions, and core competencies
- To track and analyze competitive developments such as services launches, expansions, agreements, collaborations, partnerships, and acquisitions in the market
- Micromarkets are the further segments and subsegments of the market.
- Core competencies of companies are captured in terms of the key developments, market shares, and key strategies adopted to sustain their positions in the market.
Available Customizations:
With the given market data, MarketsandMarkets offers customizations as per the company’s specific needs. The following customization options are available for the report:
- Company Information: Detailed analysis and profiling of additional market players (up to five)
- Geographic Analysis: Further breakdown of the RoE microbiome sequencing services market, by country. Further breakdown of the RoAPAC microbiome sequencing services market, by country. Further breakdown of the RoLATAM and MEA microbiome sequencing services markets, by country.
Growth opportunities and latent adjacency in Microbiome Sequencing Services Market